Negative impact of hepatitis B surface seroclearance on prognosis of hepatitis B-related primary liver cancer

World Journal of Clinical Cases
Cheng LouZhi Du

Abstract

To assess the impact of hepatitis B surface (HBsAg) seroclearance on survival outcomes in hepatitis B-related primary liver cancer. Information from patients with hepatitis B-related liver cancer admitted in our hospital from 2008-2017 was retrieved. Cases diagnosed with HBsAg (-) and HBcAb (+) liver cancer were included in the HBsAg seroclearance (SC) group. HBsAg (+) liver cancer patients strictly matched for liver cancer stage (AJCC staging system, 8th edition), Child-Pugh score, and first diagnosis/treatment method (surgery, ablation and TACE) were assigned to the HBsAg non-seroclearance (NSC) group. Then, clinical, pathological and survival data in both groups were assessed. The SC and NSC groups comprised of 72 and 216 patients, respectively. Patient age (P < 0.001) and platelet count (P = 0.001) in the SC group were significantly higher than those of the NSC group. SC group patients who underwent surgery had more intrahepatic cholangiocarcinoma (ICC) and combined HCC-CC (CHC) cases than the NSC group, but no significant differences in tumor cell differentiation and history of liver cirrhosis were found between the two groups. The numbers of interventional treatments were similar in both groups (4.57 vs 5.07, P > 0.05). O...Continue Reading

References

Aug 28, 2003·Histopathology·N D TheiseY Nakanuma
Oct 7, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Atsushi SuzukiHideki Taniguchi
Jan 21, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josephine SimonettiStephen E Livingston
Jun 11, 2010·Journal of Clinical Gastroenterology·Ji Hoon KimKwan Soo Byun
Aug 28, 2010·Journal of Gastroenterology and Hepatology·Matthew M Yeh
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Dec 6, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tetsuya HosakaHiromitsu Kumada
Aug 3, 2013·Clinics in Liver Disease·Massimo Iavarone, Massimo Colombo
Jun 11, 2014·World Journal of Gastroenterology : WJG·Hua-Bang ZhouHe-Ping Hu
Sep 26, 2014·World Journal of Gastroenterology : WJG·Yan-Ming ZhouJia-Mei Yang
Jul 15, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Sharon M WeberTimothy M Pawlik
Jun 11, 2016·Clinics and Research in Hepatology and Gastroenterology·Lian-Yuan TaoDian-Rong Xiu
Dec 22, 2016·BioMed Research International·Hao ZhangWenting Zeng
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Chern Hao Chong, Seng Gee Lim
Feb 1, 2017·Translational Gastroenterology and Hepatology·Vincent S K YipChung Mau Lo

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.