PMID: 8449206Feb 1, 1993Paper

Negative inotropy of lidocaine: possible biochemical mechanisms

European Heart Journal
R A WilsonP D Verdouw

Abstract

Previous studies have shown that lidocaine has a negative inotropic effect on the myocardium. This effect could be mediated by a decrease in O2 supply and/or utilization, or abnormalities in intracellular Ca2+ handling by the myocardium. To investigate which of these mechanisms are involved we studied nine open-chest anaesthetized pigs, which received an infusion of lidocaine (4-16 mg.min-1) in the left anterior descending coronary artery (LADCA), sufficient to induce a severe depression of the regional myocardial function. Biopsies for high energy phosphate levels were obtained from both the LADCA and control regions before and during the infusion. After measurements at peak lidocaine dose, the hearts were rapidly excised for harvesting of LADCA, and control region sarcoplasmic reticulum (SR) vesicles for in vitro measurements of Ca2+ uptake rate. During lidocaine infusion, coronary blood flow increased (23%), while ATP, Ca2+ uptake by the SR and percentage segment length shortening decreased by 20%, 19% and 30% respectively. However, O2 consumption in the LADCA region did not differ before or during lidocaine infusion (102 +/- 20 and 104 +/- 29 ml.min-1, respectively). Hence, lidocaine in doses sufficient to depress regional ...Continue Reading

Citations

Oct 18, 2003·Biochemical Pharmacology·Leonor Sterin-BordaEnri Borda
Jun 27, 2007·Journal of Palliative Medicine·Gary McCleane
Jun 1, 1996·British Journal of Pharmacology·Q PuK Samii
Jan 30, 2015·Acta Cirúrgica Brasileira·Marcelo Augusto de AraújoPaulo Sergio Patto dos Santos
Aug 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sarah J Canyon, Geoffrey P Dobson
Dec 10, 2015·Anesthesia and Analgesia·Elske SitsenJaap Vuyk
Dec 11, 1999·Canadian Journal of Physiology and Pharmacology·A A AlmotrefiN Dzimiri
Apr 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Amadou K S CamaraDavid F Stowe
May 15, 2004·American Journal of Physiology. Heart and Circulatory Physiology·David J C AldersJohannes H G M van Beek
Apr 10, 2020·Coronary Artery Disease·Wenjiang YanJingjing Yang

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