Abstract
Obesity promotes excessive inflammation, which is associated with senescence-like changes in visceral adipose tissue (VAT) and the development of type 2 diabetes (T2DM) and cardiovascular diseases. We have reported that a unique population of CD44hi CD62Llo CD4+ T cells that constitutively express PD-1 and CD153 exhibit cellular senescence and cause VAT inflammation by producing large amounts of osteopontin. Weight loss improves glycemic control and reduces cardiovascular disease risk factors, but its long-term effects on cardiovascular events and longevity in obese individuals with T2DM are somewhat disappointing and not well understood. High-fat diet (HFD)-fed obese mice were subjected to weight reduction through a switch to a control diet. They lost body weight and visceral fat mass, reaching the same levels as lean mice fed a control diet. However, the VAT of weight reduction mice exhibited denser infiltration of macrophages, which formed more crown-like structures compared to the VAT of obese mice kept on the HFD. Mechanistically, CD153+ PD-1+ CD4+ T cells are long-lived and not easily eliminated, even after weight reduction. Their continued presence maintains a self-sustaining chronic inflammatory loop via production of l...Continue Reading
References
Aug 27, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira TamuraMasaru Nasu
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabetta BugianesiGiulio Marchesini
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Kristina M Utzschneider, Steven E Kahn
Jun 27, 2009·Nutrition Research Reviews·Mary HarringtonRichard C Cottrell
Jul 28, 2009·Nature Medicine·Satoshi NishimuraRyozo Nagai
Sep 1, 2009·Nature Medicine·Tohru MinaminoIssei Komuro
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kenichiro ShimataniNagahiro Minato
Mar 3, 2010·European Journal of Clinical Investigation·Panagiota GeorgiadouDimitrios T Kremastinos
Aug 13, 2010·Aging Cell·Tamara TchkoniaJames L Kirkland
Sep 30, 2010·The Journal of Clinical Investigation·Aliki KosteliAnthony W Ferrante
Aug 3, 2012·Diabetes Care·Stefano RomeoLena M S Carlsson
Jun 26, 2013·The New England Journal of Medicine·Rena R WingSusan Z Yanovski
Jun 6, 2014·Nature·Rachel J PerryGerald I Shulman
May 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suhail TahirNagahiro Minato
Oct 20, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Fabian Sanchis-GomarAlejandro Lucia
Apr 26, 2016·Molecular Metabolism·J SchmitzJ C Brüning
Jun 11, 2016·PloS One·Ahmed D AbdalrhimIftikhar J Kullo
Nov 8, 2016·The Journal of Clinical Investigation·Kohsuke ShirakawaMotoaki Sano
Citations
May 9, 2018·Endocrine·Marek StrączkowskiMonika Karczewska-Kupczewska
Apr 6, 2019·PloS One·Bettina WankoThomas M Stulnig
Feb 6, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Bjorn T TamSylvia Santosa
Jan 23, 2020·International Immunology·Nagahiro MinatoYoko Hamazaki
Feb 8, 2020·Obesity·Isaiah JanumalaDympna Gallagher
Jan 27, 2019·PloS One·Kohsuke ShirakawaMotoaki Sano
Aug 11, 2020·Immunometabolism·Alecia M BlaszczakWilla A Hsueh
Jan 4, 2019·Inflammation and Regeneration·Yuji FukushimaMasakazu Hattori
Jul 12, 2018·Current Hypertension Reports·Thierry H Le JemtelSuzanne Oparil
Jun 6, 2018·Frontiers in Endocrinology·Luz AndreoneMarcelo J Perone
Oct 25, 2020·Scientific Reports·Ming-Chieh TsaiKuo-Liong Chien
Jun 19, 2021·PloS One·Xiaoxiang YanKen Shinmura
Aug 7, 2021·Biomolecules·Kohsuke Shirakawa, Motoaki Sano
Nov 14, 2021·Scientific Reports·Ming-Chieh TsaiKuo-Liong Chien