Negative Lymph Node Count Predicts Survival of Resected Non-small Cell Lung Cancer.

Lung
Xinyan ZhouQi Cheng

Abstract

The purpose of this study was to explore the association between the negative lymph node (NLN) count and survival, as well as compare the prognostic value of the positive lymph node (PLN) count, lymph node ratio (the PLN count/total lymph nodes examined, LNR), and NLN count in patients with non-small cell lung cancer (NSCLC). We identified patients diagnosed with NSCLC between 2005 and 2011 from the Surveillance, Epidemiology, and End Results database. Outcomes of interest were lung cancer-specific survival (LCSS) and overall survival (OS). Cases were divided into several groups based on the PLN count, NLN count, and LNR. The prognostic significance of the PLN count, NLN count, and LNR models was analyzed with the Kaplan-Meier method and the Cox regression model. 39,959 patients with surgical resection for NSCLC were identified. Univariate analysis demonstrated that a greater count of NLNs was associated with better LCSS (P < 0.001) and OS (P < 0.001). Subgroup analysis showed that the NLN count could predict survival in both node-negative and node-positive patients. Multivariable analysis revealed that the NLN count was an independent prognostic factor for LCSS and OS. The NLN count is an independent prognostic factor of OS an...Continue Reading

References

Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L CampDavid L Rimm
Aug 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul M JohnsonNancy N Baxter
Aug 5, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B Kuru
Apr 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Per KarlssonArne Wallgren
Mar 24, 2012·The Annals of Thoracic Surgery·Chukwumere E NwoguMary Reid
Sep 4, 2013·The Annals of Thoracic Surgery·Matthew D TaylorDavid R Jones
Sep 24, 2015·Oncotarget·Guangyuan SunXuewei Zhao
Jan 15, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee Advisory Boards and Particip
Nov 26, 2016·World Journal of Surgical Oncology·Masaya TamuraHirofumi Takemura
Mar 21, 2017·Surgical Oncology·Dariusz DziedzicUNKNOWN Polish Lung Cancer Study Group (PLCSG)
Jul 24, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Weiye DengZhongxing Liao
Aug 11, 2018·Clinical Breast Cancer·Fatma Abd-Elshahed Abd-ElhayNguyen Tien Huy
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Jan 27, 2021·Lung·Peter V Dicpinigaitis

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