Negative motivational control of saccadic eye movement by the lateral habenula.

Progress in Brain Research
Masayuki Matsumoto, Okihide Hikosaka

Abstract

Reward is crucial for survival of animals and influences animal behaviours. For example, an approaching behaviour to reward is more frequently and quickly elicited when a big reward is expected than when a small reward is expected. Midbrain dopamine neurons are thought to be crucial for such reward-based control of motor behaviour. Indeed, dopamine neurons are excited by cues predicting reward and inhibited by cues predicting no-reward. These excitatory and inhibitory signals would then be used for enhancing and depressing sensorimotor processing, respectively, in the brain areas targeted by dopamine neurons (e.g., striatum). However, it was unknown which parts of the brain provide dopamine neurons with reward-related signals necessary for their responses. We recently showed evidence that the lateral habenula transmits reward-related signals to dopamine neurons, especially to inhibit dopamine neurons. This recent study suggested that the lateral habenula suppresses less rewarding saccadic eye movements by inhibiting dopamine neurons. In the present review, we first summarize anatomical and functional aspects of the lateral habenula. We will then describe our own study. Finally, we will discuss how the lateral habenula, as well ...Continue Reading

Citations

Jun 26, 2017·Pharmacology, Biochemistry, and Behavior·Daniel S Zahm, David H Root
Aug 23, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emma Jane RoseElliot A Stein
Mar 10, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas Wichmann, Mahlon R DeLong
Apr 10, 2020·Nature Reviews. Neuroscience·Hailan HuYan Yang
Dec 12, 2020·Current Opinion in Neurobiology·Masaki Isoda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.