Negative Predictive Value of NI-RADS Category 2 in the First Posttreatment FDG-PET/CT in Head and Neck Squamous Cell Carcinoma

AJNR. American Journal of Neuroradiology
P WangaryattawanichT J Rath

Abstract

FDG PET/CT has a high negative predictive value in patients with head and neck squamous cell carcinoma who responds completely to non-operative therapy. However, the treatment failure rate in patients with a partial but incomplete response is unclear. Our aim was to investigate the negative predictive value of the first posttreatment FDG-PET/CT in patients with head and neck squamous cell carcinoma with incomplete response interpreted as Neck Imaging Reporting and Data System (NI-RADS) category 2. We retrospectively identified patients with head and neck squamous cell carcinoma treated with chemoradiation or radiation therapy with curative intent in our institution between 2008 and 2016. We included patients whose first posttreatment FDG-PET/CT was interpreted as showing marked improvement of disease but who had a mild residual mass or FDG avidity in either the primary tumor bed or lymph nodes (NI-RADS 2). The negative predictive value of FDG-PET/CT was calculated, including the 95% CI, using the Newcombe method. Two-year disease-free survival was the reference standard. Seventeen of 110 patients (15%) experienced locoregional treatment failure within 2 years of completing treatment, yielding a negative predictive value of 85% ...Continue Reading

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Citations

Sep 3, 2020·AJR. American Journal of Roentgenology·Sara B StraussC Douglas Phillips
May 30, 2020·Journal of Computer Assisted Tomography·Ahmed Abdel Khalek Abdel Razek, Tougan Taha Abdelaziz
Aug 20, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Tougan Taha AbdelazizAhmed S Abdelrahman
Feb 26, 2020·Japanese Journal of Radiology·Takashi HiyamaTatsushi Kobayashi
Mar 13, 2021·AJNR. American Journal of Neuroradiology·M M AshourT T Abdelaziz
Sep 3, 2020·AJR. American Journal of Roentgenology·Patrick DinkelborgFabian Henry Jürgen Elsholtz

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