Negative pressure wound therapy for managementof the surgical incision in orthopaedic surgery: A review of evidence and mechanisms for an emerging indication

Bone & Joint Research
S KarlakkiR Martin

Abstract

The period of post-operative treatment before surgical wounds are completely closed remains a key window, during which one can apply new technologies that can minimise complications. One such technology is the use of negative pressure wound therapy to manage and accelerate healing of the closed incisional wound (incisional NPWT). We undertook a literature review of this emerging indication to identify evidence within orthopaedic surgery and other surgical disciplines. Literature that supports our current understanding of the mechanisms of action was also reviewed in detail. A total of 33 publications were identified, including nine clinical study reports from orthopaedic surgery; four from cardiothoracic surgery and 12 from studies in abdominal, plastic and vascular disciplines. Most papers (26 of 33) had been published within the past three years. Thus far two randomised controlled trials - one in orthopaedic and one in cardiothoracic surgery - show evidence of reduced incidence of wound healing complications after between three and five days of post-operative NPWT of two- and four-fold, respectively. Investigations show that reduction in haematoma and seroma, accelerated wound healing and increased clearance of oedema are sig...Continue Reading

References

Oct 18, 2001·Plastic and Reconstructive Surgery·A J DeFranzoR G Teasdall
Oct 11, 2002·The Journal of the American Academy of Orthopaedic Surgeons·Lawrence X Webb
Apr 15, 2004·Burns : Journal of the International Society for Burn Injuries·L-P KamolzM Frey
Nov 24, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Angelica WackenforsMalin Malmsjö
Sep 15, 2005·Circulation·Vance G FowlerEric D Peterson
Jul 13, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ludwig LablerMichael Heinzelmann
Aug 29, 2006·The Journal of Thoracic and Cardiovascular Surgery·Ravi KarraKeith S Kaye
Nov 16, 2006·Journal of Orthopaedic Trauma·Andreas H GomollMitchel B Harris
May 13, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Shigeru IchiokaTakashi Nakatsuka
Sep 9, 2008·Seminars in Vascular Surgery·Dennis F Bandyk
Feb 3, 2009·Plastic and Reconstructive Surgery·Nicolas KairinosMichael Solomons
May 23, 2009·Surgical Innovation·Broadus Zane AtkinsWalter G Wolfe
Aug 26, 2009·Journal of Orthopaedic Trauma·James P StannardJorge E Alonso
Oct 8, 2009·Acta orthopaedica et traumatologica turcica·Ayhan KiliçYavuz Kabukçuoğlu
Jul 8, 2010·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·William T DeCarbo, Christopher F Hyer
Jan 11, 2011·Annals of Surgery·Paolo ErbaDennis P Orgill
Mar 23, 2011·American Journal of Surgery·C M MouësS E R Hovius
Jun 15, 2011·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M López-Cano, M Armengol-Carrasco
Jul 16, 2011·International Orthopaedics·Milena PachowskyMatthias H Brem
Aug 2, 2011·Journal of Orthopaedic Trauma·James P StannardJeffrey O Anglen
Aug 27, 2011·Surgical Innovation·Robert Peyton WilkesAmy McNulty
Nov 19, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Deepak V Kilpadi, Mark R Cunningham
Nov 19, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ola BorgquistMalin Malmsjö
Dec 6, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·S U EisenhardtH Bannasch
Apr 11, 2012·Journal of Orthopaedic Trauma·Martin L BlumFranklin L Rosenfeldt
Jun 29, 2012·International Wound Journal·James P StannardBurkhard Lehner
Aug 14, 2012·Journal of Wound Care·M Dutton, K Curtis
Sep 6, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Gregg W SchmedesJudith M Skoner
Oct 31, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Robert TauberTobias Maurer
Nov 1, 2012·The Journal of Thoracic and Cardiovascular Surgery·Onnen GrauhanRoland Hetzer

❮ Previous
Next ❯

Citations

May 24, 2014·Current Oncology Reports·Justin E Bird
Dec 19, 2015·Bone & Joint Research·A H R W SimpsonM Ghert
May 2, 2015·International Wound Journal·Matthias NordmeyerMatthias H Brem
Mar 21, 2016·The British Journal of Surgery·N HyldigC Bille
Jul 18, 2015·Bone & Joint Research·A H R W Simpson
Mar 7, 2015·The Veterinary Clinics of North America. Small Animal Practice·Lisa M Howe
Jan 9, 2015·Obstetrics and Gynecology·Nelson C EchebiriVanessa M Barnabei
Jun 5, 2014·Ophthalmic Plastic and Reconstructive Surgery·José Contreras-RuizRubén Lopez-Oliver
May 14, 2016·International Wound Journal·Christian WillyV Sreenath Reddy
Oct 4, 2016·International Wound Journal·Stephen S CaiYvonne M Rasko
Mar 5, 2015·Foot & Ankle International·Takumi Matsumoto, Selene G Parekh
Jul 16, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A Zaidi, S El-Masry
Apr 4, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Leo M NhereraSudheer L Karlakki
Jan 30, 2018·International Orthopaedics·Siem A DingemansTim Schepers
Mar 9, 2018·Annals of Vascular Diseases·Kah Wei TanSadhana Chandrasekar
Oct 8, 2014·The Cochrane Database of Systematic Reviews·Joan WebsterWendy P Chaboyer
Apr 9, 2015·British Journal of Hospital Medicine·Rachel Holt, John Murphy
Apr 9, 2015·Journal of Wound Care·Raymund E Horch
Jun 9, 2015·British Journal of Community Nursing·Hussam Eddine Itani
Dec 21, 2017·The Journal of the American Academy of Orthopaedic Surgeons·Julia A KatarincicRoss Feller
Dec 27, 2018·Plastic and Reconstructive Surgery·Devinder SinghTripp Holton
Dec 27, 2018·Plastic and Reconstructive Surgery·Animesh Agarwal
Jul 30, 2014·The Open Orthopaedics Journal·Sven PutnisJames M-L Wong
Mar 27, 2019·The Cochrane Database of Systematic Reviews·Joan WebsterWendy P Chaboyer
Aug 10, 2019·Journal of Comparative Effectiveness Research·Lei WangJun Liu
Oct 10, 2019·The Journal of Bone and Joint Surgery. American Volume·Hansel Gould B CocjinJose Maria R Coruña
Feb 19, 2020·Journal of Wound Care·Jan StryjaDeborah Xuereb
May 2, 2020·The Cochrane Database of Systematic Reviews·Gill NormanAdam Reid
Mar 28, 2017·Journal of Wound Care·Jan ApelqvistPeter Vowden
Jun 17, 2020·The Cochrane Database of Systematic Reviews·Gill NormanAdam Reid
Jun 24, 2017·Acta ortopedica brasileira·Camilo Partezani HelitoMarco Kawamura Demange

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass
dissection
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
P VikatmaaA Malmivaara
The New Zealand Medical Journal
James JohnstonDavid Vokes
© 2021 Meta ULC. All rights reserved