Negative prognostic influence of micropapillary pattern in stage IA lung adenocarcinoma

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Norifumi TsubokawaMorihito Okada

Abstract

There is uncertainty as to which factors determine the aggressiveness of lung adenocarcinoma with a micropapillary pattern (MPP). The present study aimed to clarify the influence of a MPP on the malignant aggressiveness of clinical stage IA lung adenocarcinoma. We retrospectively examined 347 consecutive patients with clinical stage IA lung adenocarcinoma who underwent complete resection. We defined MPP-positive as accounting for ≥5% of the entire tumour. Forty-eight (14%) and 299 (86%) patients were MPP-positive and negative, respectively. Lymphatic (P = 0.003) and vessel (P = 0.029) invasion as well as lymph node metastasis (P = 0.002) were more frequent in the MPP-positive than negative group. Five-year disease-free survival (DFS) rates were significantly lower in the MPP-positive than negative group (69.7 vs 89.3%, P < 0.001). Multivariate analysis for DFS showed that MPP (P = 0.048), lymphatic invasion (P = 0.003) and vessel invasion (P = 0.002) were independent poor prognostic factors. In addition, higher proportions (<5%, 5-30% and ≥30%) of MPP were associated with a poorer prognosis (89.3, 76.0, and 48.1%, respectively; P < 0.001). The prognosis of patients with MPP-positive tumours and negative tumours harbouring lepid...Continue Reading

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Citations

Aug 28, 2016·Japanese Journal of Clinical Oncology·Norifumi TsubokawaMorihito Okada
Sep 8, 2016·Interactive Cardiovascular and Thoracic Surgery·Ze-Rui ZhaoCalvin S H Ng
Apr 4, 2018·Virchows Archiv : an International Journal of Pathology·Tamás ZomboriJózsef Furák
Feb 1, 2020·Expert Review of Anticancer Therapy·Aaron R Dezube, Michael T Jaklitsch
Mar 1, 2017·General Thoracic and Cardiovascular Surgery·Yukihiro YoshidaJun Nakajima
May 21, 2019·Interactive Cardiovascular and Thoracic Surgery·Yuriko TeradaJun Nakajima
Jul 29, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Katsura EmotoPrasad S Adusumilli
Mar 11, 2021·American Journal of Respiratory and Critical Care Medicine·Menaka MahendranPeruvemba Sriram
Jul 1, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Katsura EmotoWilliam D Travis

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