PMID: 11932204Apr 5, 2002Paper

Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids

Journal of Molecular Endocrinology
Wassim Y Almawi, O K Melemedjian

Abstract

Glucocorticoids (GCs) exert their anti-inflammatory and antiproliferative effects principally by inhibiting the expression of cytokines and adhesion molecules. Mechanistically, GCs diffuse through the cell membrane, and bind to their inactive cytosolic receptors (GRs), which then undergo conformational modifications that allow for their nuclear translocation. In the nucleus, activated GRs modulate transcriptional events by directly associating with DNA elements, compatible with the GCs response elements (GRE) motif, and located in variable copy numbers and at variable distances from the TATA box, in the promoter region of GC-responsive genes. In addition, activated GRs also acted by antagonizing the activity of transcription factors, in particular nuclear factor-kappaB (NF-kappaB), by direct and indirect mechanisms. GCs induced gene transcription and protein synthesis of the NF-kappaB inhibitor, IkappaB. Activated GR also antagonized NF-kappaB activity through protein-protein interaction involving direct complexing with, and inhibition of, NF-kappaB binding to DNA (Simple Model), or association with NF-kappaB bound to the kappaB DNA site (Composite Model). In addition, and according to the Transmodulation Model, GRE-bound GR ma...Continue Reading

Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Jeffrey G Wright, John W Christman
Mar 22, 2007·Pediatric Cardiology·K J MillarP C Laussen
Feb 14, 2004·American Journal of Ophthalmology·Stephen C Pflugfelder
Feb 14, 2013·Molecular and Cellular Endocrinology·Cindy Strehl, Frank Buttgereit
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Tamsin Lindstrom, Phillip Bennett
Oct 18, 2003·Seminars in Immunology·Lisa M Minter, Barbara A Osborne
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·S R Price
Aug 7, 2003·Current Opinion in Pharmacology·Luke A J O'Neill
Dec 5, 2002·Clinical and Experimental Dermatology·G Belgi, P S Friedmann
Dec 21, 2002·The British Journal of Nutrition·George FrancisKlaus Becker
Jun 28, 2003·Viral Immunology·Michael BaileyJohn F Sheridan
Sep 29, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Eric R James
Mar 8, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kaevalin LekhanontRoy S Chuck
Jun 28, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xuemei FangJiayin Dai
Feb 7, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xuemei FangJiayin Dai
Apr 7, 2007·Critical Care Medicine·Susannah K LeaverTimothy W Evans
Oct 1, 2008·Cornea·Stephen C PflugfelderMichael E Stern
Apr 16, 2009·Clinical Microbiology Reviews·Trine H Mogensen
Mar 23, 2011·Infection and Immunity·Diana Diaz-ArevaloMarkus Kalkum
Jul 18, 2012·Molecular and Cellular Biology·Timothy E ReddyRichard M Myers
May 18, 2005·Skin Pharmacology and Physiology·M Schafer-KortingH C Korting
Jul 10, 2004·American Journal of Respiratory Cell and Molecular Biology·Toshiki HommaKenji Matsumoto
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carolina Demarchi MunhozRobert M Sapolsky
Feb 13, 2016·Frontiers in Endocrinology·Andrea Rodrigues VasconcelosElisa Mitiko Kawamoto
Apr 23, 2013·The Annals of Thoracic Surgery·Christopher W MastropietroHenry L Walters

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