Negative regulation of resistance protein-mediated immunity by master transcription factors SARD1 and CBP60g

Journal of Integrative Plant Biology
Tongjun SunXin Li

Abstract

Salicylic acid (SA) is an essential defence hormone in plants. Upon pathogen infection, induced biosynthesis of SA is mediated by Isochorismate synthase 1 (ICS1), whose gene transcription is controlled mainly through two redundant transcription factors, SAR Deficient 1 (SARD1) and Calmodulin-binding protein 60-like g (CBP60g). Although these master transcription factors regulate not only positive, but also negative regulators of immunity, how they control signaling events downstream of different immune receptors is unclear. Using autoimmune mutants activating immunity mediated by different receptors we show that, although the sard1 cbp60g double mutant almost fully suppresses the activation of defence mediated by suppressor of npr1-1, constitutive 2 (snc2), it strikingly enhances snc1, which carries a gain-of-function mutation in an intracellular nucleotide-binding leucine-rich repeat (NLR) immune receptor. This negative regulation of immunity is achieved through the transcriptional regulation of negative regulators, such as Nudix hydrolase homolog 6 (NUDT6). Our study highlights the diverse roles, especially the negative ones, in the regulation of plant immunity by the two master immune transcription factors SARD1 and CBP60g.

References

Jul 31, 2004·Annual Review of Phytopathology·W E Durrant, X Dong
Jun 30, 2010·Nature Reviews. Genetics·Peter N Dodds, John P Rathjen
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yaxi ZhangYuelin Zhang
May 28, 2011·The Plant Journal : for Cell and Molecular Biology·Lin WangJane Glazebrook
Aug 20, 2011·Nature Immunology·Takaki MaekawaPaul Schulze-Lefert
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yu Ti ChengXin Li
Feb 23, 2013·Cold Spring Harbor Symposia on Quantitative Biology·K C M JohnsonX Li
Jan 1, 2015·Nature Communications·Tongjun SunYuelin Zhang
Aug 12, 2016·Cell Host & Microbe·Shuai HuangXin Li
Dec 10, 2016·Science·Jonathan D G JonesJeffery L Dangl

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