Negative regulation of the thyroid-stimulating hormone alpha gene by thyroid hormone: receptor interaction adjacent to the TATA box.

Proceedings of the National Academy of Sciences of the United States of America
V K ChatterjeeJ L Jameson

Abstract

Thyroid-stimulating hormone alpha and beta subunit genes are negatively regulated by thyroid hormone at the transcriptional level. Transient gene expression studies were used to demonstrate that the erbA beta form of the thyroid hormone receptor mediates negative regulation of the alpha-subunit promoter in a hormone-dependent manner. In JEG-3 choriocarcinoma cells, which are deficient in thyroid hormone receptors, coexpression of erbA beta with alpha CAT reporter genes markedly suppressed alpha CAT expression after treatment with thyroid hormone, whereas a reporter gene containing a known positive thyroid response element was induced. Thus, a single form of thyroid hormone receptor mediates both positive and negative responses to thyroid hormone in this system. Transient expression analyses of alpha gene 5' flanking sequence deletion mutants localized the negative thyroid response element to the proximal region of the promoter between -100 and +4 base pairs. The location of the negative thyroid response element in the alpha gene is therefore distinct from that of previously identified regulatory elements including the tissue-specific upstream regulatory elements, the cAMP response elements, and the glucocorticoid response eleme...Continue Reading

References

May 1, 1975·The Journal of Clinical Endocrinology and Metabolism·I A KouridesF Maloof
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B J SilverJ H Nilson
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M C AlexanderC Ramaika
Dec 18, 1986·Nature·C WeinbergerR M Evans
Apr 1, 1988·The Journal of Clinical Investigation·H H SamuelsZ S Ye
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T A Kunkel
Apr 1, 1973·Virology·F L Graham, A J van der Eb
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A M SinhaM Rabinowitz

❮ Previous
Next ❯

Citations

Jul 20, 2007·Pituitary·Clement C Cheung, Robert H Lustig
Dec 14, 1993·Biochimica Et Biophysica Acta·M T AkbariD B Ramsden
Sep 1, 1993·Molecular and Cellular Endocrinology·J B TillmanS R Spindler
Feb 1, 1993·Molecular and Cellular Endocrinology·K E JonesW W Chin
Dec 11, 1990·Biochimica Et Biophysica Acta·C K Glass, J M Holloway
Sep 14, 1992·Biochimica Et Biophysica Acta·M L Privalsky
Aug 15, 2000·Molecular and Cellular Endocrinology·N Messier, M F Langlois
Mar 26, 2002·Molecular and Cellular Endocrinology·Thierry Van ReethJosiane Szpirer
Apr 4, 1997·Molecular and Cellular Endocrinology·T TakedaL J DeGroot
Oct 31, 2001·Differentiation; Research in Biological Diversity·J H SeagerB D Hames
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y YaoitaD D Brown
Jul 12, 2003·Thyroid : Official Journal of the American Thyroid Association·Yasuhiro Ota, Cary N Mariash
Nov 25, 1994·Nucleic Acids Research·B MartinM Muller
Jun 11, 1993·Annals of the New York Academy of Sciences·R Renkawitz
Jun 1, 1991·The Journal of Clinical Investigation·V K ChatterjeeJ L Jameson
Jan 23, 1999·The Journal of Clinical Investigation·E D AbelF E Wondisford
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Danielle S MachadoFredric E Wondisford
May 1, 2013·The Journal of Biological Chemistry·Pragya SharmaEdwards A Park
Oct 27, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kazuhiro ShiizakiTakashi Yagi
Jul 8, 1991·Biochemical and Biophysical Research Communications·D W CookeS J Casella
Aug 25, 2007·Biochemical and Biophysical Research Communications·Marie-Belle PoirierMarie-France Langlois
Aug 28, 2007·Journal of Molecular and Cellular Cardiology·Mahesh P Gupta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.