Negative regulation of YY1 transcription factor on the dynamin I gene promoter

Biochemical and Biophysical Research Communications
J YooM Y Han

Abstract

Dynamin I is highly expressed in brain and plays a critical role in clathrin-mediated endocytosis and synaptic vesicle recycling. To elucidate the molecular mechanism by which expression of dynamin I is tissue-specifically regulated, we previously cloned and characterized the promoter of the mouse dynamin I gene and suggested that there is a negative regulatory element in this promoter region. In the present study, we showed that YY1 binds to this negative regulatory element located at -111 to -107 by using the EMSA and supershift analyses. Cotransfection experiment using an YY1 expression vector revealed that YY1 exerts a repressive role on the dynamin I gene promoter activity. These results demonstrate that transcription factor YY1 negatively regulates dynamin I expression via binding to the negative regulatory element.

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Citations

May 20, 2008·Journal of Neurochemistry·Ye He, Patrizia Casaccia-Bonnefil
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Chi-Chung WangPan-Chyr Yang
Jun 28, 2008·Neurochemical Research·Marcin RylskiLeszek Kaczmarek

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