PMID: 6966318May 1, 1980Paper

Negative selection of T cells causing lethal graft-versus-host disease across minor histocompatibility barriers. Role of the H-2 complex

The Journal of Experimental Medicine
Robert Korngold, J Sprent

Abstract

With a model in which CBA T cells cause lethal graft-versus-host disease (GVHD) in irradiated B10.BR mice (H-2-compatible mice that express multiple minor histocompatibility antigen [HA] differences), information was sought on whether the induction phase of GVHD to minor HA is H-2 restricted. When unprimed CBA (H-2k) T cells were recirculated from blood to lymph for 1 d through irradiated H-2-compatible B10.BR or B10.K mice, the T cells underwent specific negative selection to the minor HA of the host, i.e, the filtered T cells failed to cause GVHD after transfer to B10.BR mice. With filtration through totally H-2-different B10 (H-2b), B10.D2 (H-2d), or B10.S (H-2s) mice, by contrast, no selection occurred, i.e., the filtered cells were unimpaired in their capacity to kill B10.BR mice. Selection was marked after filtration through H-2-semiallogeneic (B10 X CBA)F1 mice. These data, together with the results of filtering T cells through various H-2 recombinant strains, indicated that selection depended upon the donor and filtration host sharing determinants encoded by both the K- and D-ends of the H-2 complex. Compatibility only in the I region failed to cause demonstrable selection.

References

Jan 1, 1977·Immunological Reviews·E Simpson, R D Gordon
Nov 1, 1979·The Journal of Experimental Medicine·H von Boehmer, W Haas
Jan 1, 1977·Immunological Reviews·H Cantor, E A Boyse
Nov 1, 1975·The Journal of Experimental Medicine·R D GordonL E Samelson
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J F MillerJ Gamble

❮ Previous
Next ❯

Citations

Aug 1, 1980·Springer Seminars in Immunopathology·J SprentK Molnar-Kimber
Dec 10, 2003·Experimental Hematology·Warren D Shlomchik
Apr 7, 2007·The Journal of Experimental Medicine·Hema Bashyam
Jul 15, 2011·Immunotherapy·Takanori TeshimaKatsutoshi Ozaki
Oct 1, 1983·Clinics in Haematology·R Korngold, J Sprent
Feb 2, 2010·Immunology and Allergy Clinics of North America·Sung W ChoiJames L M Ferrara
Sep 29, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Yaping SunPavan Reddy
Dec 13, 2006·European Journal of Immunology·Daigo HashimotoTakanori Teshima
Jan 18, 2006·Seminars in Hematology·James L M Ferrara, Pavan Reddy
Nov 13, 2013·Seminars in Hematology·Caroline ArberPavan Reddy
Apr 15, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sumit ChawlaJan Storek
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·H Bril, R Benner
Feb 16, 2021·Frontiers in Immunology·Carina A BäuerleinAndreas Beilhack

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.