Negative symptoms: clinical and psychometric aspects

L'Encéphale
Marc AdidaE Fakra

Abstract

Recent investigations performing exploratory and confirmatory factor analysis have suggested that negative symptoms are multidimensional, including evidence for at least two distinct negative symptom subdomains: diminished expression and amotivation. Guidance for selection of instruments for measurement of negative symptoms is rapidly evolving. As there are continuing advances in the description of negative symptoms, new instruments are under development, and new data on the performance of instruments emerge from clinical trials. The Scale for Assessment of Negative Symptoms (SANS), the Positive and Negative Syndrome Scale (PANSS), and the Negative Symptom Assessment-16 (NSA-16) are considered to be reliable and valid measures for negative symptom trials but differ with respect to their domain coverage, use of informants, integration of global scores, administration time and comprehensiveness of their structured interviews. In response to the 2005 NIMH - MATRICS consensus statement, work groups are field testing and refining two new measures, the Clinical Assessment Interview for Negative Symptoms (CAINS) and the Brief Negative Symptom Scale (BNSS). Both address the five currently recognized domains of negative symptoms, differ...Continue Reading

References

Feb 17, 2006·Schizophrenia Bulletin·Brian KirkpatrickStephen R Marder
Jan 29, 2011·Schizophrenia Bulletin·Stephen R MarderRichard S E Keefe
Oct 16, 2012·Schizophrenia Research·Gregory P StraussBrian Kirkpatrick
Feb 5, 2013·The American Journal of Psychiatry·Ann M KringSteven P Reise

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