PMID: 9543206Jul 21, 1998Paper

Negative symptoms, depression, and parkinsonian symptoms in chronic, hospitalised schizophrenic patients

Journal of Affective Disorders
A PerenyiG Burrows

Abstract

Negative symptoms of schizophrenia are often confounded by overlapping depressive and parkinsonian symptoms. The role of medication as an aetiological factor in the development of these symptoms is an important issue for prevention and treatment. A total of 45 inpatients in chronic wards who met RDC criteria for schizophrenia were assessed with the Hamilton depression rating scale (HDRS) and negative symptom rating scale (NSRS) and the targeting abnormal kinetic effect scale (TAKE). No significant correlation was found between the total scores on the vegetative superfactor of the HDRS and the NSRS. Duration of neuroleptic treatment was positively correlated with depressive symptoms (r=0.299, P < 0.05) and negative symptoms (r=0.443, P < 0.001). Dose of antipsychotic was also correlated positively with negative symptoms (r=0.260, P < 0.05). Age was negatively correlated with depressive symptoms as assessed by the HDRS (r=0.306, P <0.05). The data suggest that depressive and negative symptoms can be separated in chronic schizophrenia, while pointing to a possible role of antipsychotic medication in the aetiology. The study was conducted in a small chronically hospitalised population treated with relatively high doses of antipsych...Continue Reading

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Citations

Jul 5, 2005·European Archives of Psychiatry and Clinical Neuroscience·Hans-Jürgen Möller
Oct 2, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·L RabanyY Levkovitz
May 4, 2016·Psychiatry Research·Vjekoslav PeitlDalibor Karlović
Jul 21, 2004·Psychiatry Research·Alessandro SerrettiEnrico Smeraldi
Nov 26, 2013·Schizophrenia Research·Jung Suk LeeJae-Jin Kim
Feb 7, 2008·The Cochrane Database of Systematic Reviews·V A Furtado, V Srihari
Feb 13, 2009·Medicine, Health Care, and Philosophy·Jeanette Hewitt
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·H J Möller
Aug 28, 2009·Medical Education·Christine B Phillips

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