Negative symptoms in schizophrenia: a study in a large clinical sample of patients using a novel automated method

BMJ Open
Rashmi PatelRobert Stewart

Abstract

To identify negative symptoms in the clinical records of a large sample of patients with schizophrenia using natural language processing and assess their relationship with clinical outcomes. Observational study using an anonymised electronic health record case register. South London and Maudsley NHS Trust (SLaM), a large provider of inpatient and community mental healthcare in the UK. 7678 patients with schizophrenia receiving care during 2011. Hospital admission, readmission and duration of admission. 10 different negative symptoms were ascertained with precision statistics above 0.80. 41% of patients had 2 or more negative symptoms. Negative symptoms were associated with younger age, male gender and single marital status, and with increased likelihood of hospital admission (OR 1.24, 95% CI 1.10 to 1.39), longer duration of admission (β-coefficient 20.5 days, 7.6-33.5), and increased likelihood of readmission following discharge (OR 1.58, 1.28 to 1.95). Negative symptoms were common and associated with adverse clinical outcomes, consistent with evidence that these symptoms account for much of the disability associated with schizophrenia. Natural language processing provides a means of conducting research in large representativ...Continue Reading

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Apr 16, 1998·The British Journal of Psychiatry : the Journal of Mental Science·J K WingA Burns
Sep 24, 2005·Schizophrenia Bulletin·David KimhyDolores Malaspina
Feb 17, 2006·Schizophrenia Bulletin·Brian KirkpatrickStephen R Marder
Sep 14, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Markus JägerHans-Jürgen Möller
Jun 19, 2010·Schizophrenia Bulletin·Brian KirkpatrickStephen R Marder
Jan 5, 2011·Psychiatry Research·Alp ÜçokPınar Elif Kandemir
Feb 5, 2011·The British Journal of Psychiatry : the Journal of Mental Science·R Jacobs, E Barrenho
Apr 8, 2011·Expert Review of Neurotherapeutics·Gary RemingtonGeorge Foussias
May 24, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·R Hunter, S Barry
Oct 5, 2011·Psychiatric Services : a Journal of the American Psychiatric Association·Mark OlfsonSteven C Marcus
Jan 25, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Carl I CohenDishal Solanki
Feb 15, 2013·PLoS Computational Biology·Hamish CunninghamKalina Bontcheva
Jul 12, 2013·BMC Medical Informatics and Decision Making·Andrea C FernandesFelicity Callard
Aug 14, 2013·Schizophrenia Research·Celso ArangoStephen R Marder
Dec 3, 2013·Therapeutic Advances in Psychopharmacology·Kevin C ReevesAnne-Marie Duchemin

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Citations

Feb 6, 2016·Social Psychiatry and Psychiatric Epidemiology·J Das-MunshiM J Prince
Jun 14, 2016·Schizophrenia Research·André AlemanHenderikus Knegtering
Apr 23, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Rashmi PatelPhilip McGuire
Jul 29, 2016·Social Psychiatry and Psychiatric Epidemiology·Robert Stewart, Katrina Davis
Oct 4, 2016·The Lancet. Psychiatry·Andrew M McIntoshUNKNOWN MQ Data Science Group
Mar 24, 2017·Acta Psychiatrica Scandinavica·C NúñezC Stephan-Otto
Jan 26, 2018·Schizophrenia Bulletin·Johnny DownsLaura Pina-Camacho
Oct 31, 2017·Journal of Market Access & Health Policy·A MillierM Toumi
Oct 11, 2019·Schizophrenia Bulletin·Andrea Pelletier-Baldelli, Daphne J Holt
Sep 9, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert Stewart, Sumithra Velupillai
Aug 7, 2018·BJPsych Advances
Dec 27, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A B SmulevichO Yu Sorokina
Oct 23, 2019·CNS Neuroscience & Therapeutics·Maria Chiara SpanoMassimo di Giannantonio
Jan 14, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sélim Benjamin GuessoumJasmina Mallet
Mar 20, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·Sharvari KhapreClare Taylor
Jun 1, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jasmina MalletCaroline Dubertret
May 5, 2021·Journal of Medical Internet Research·Aziliz Le GlazChristophe Lemey
Jun 1, 2021·Revista de psiquiatrí́a y salud mental·Gurpreet RekhiJimmy Lee
Sep 4, 2021·Journal of Medical Internet Research·Samira Abbasgholizadeh RahimiJean Légaré

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Software Mentioned

Clinical Record Interactive Search ( CRIS )
CRIS
NSS
Generalised Architecture for Text Engineering ( GATE )

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