Negative symptoms in schizophrenia and substance-related disorders

L'Encéphale
N SimonJ-M Azorin

Abstract

Dual diagnosis of schizophrenia and substance-related disorders is common in psychiatric practice. Epidemiologic studies and report have established that the risk of a substance-related disorder was 4 to 5 times higher in a population of psychiatric patients than in the general population. However, little is known on the reason of this relationship and the treatments required. It's well known that a family history of psychosis is a risk factor of schizophrenia. Similarly a family history of substance use disorders increases the risk of using substances. Because the two disorders often occurred together, it could be hypothesized that a genetic risk factor is common. However, recent studies did not confirm this hypothesis and it seems that their genetic risks factor would be unrelated. Evidence now exists describing the different profiles of patients whether they used substance or not. Concerning negative symptoms clinical studies and meta-analyses have described fewer symptoms in schizophrenia patients with a substance use disorder. Among the different explanations that have been addressed, it seems that a lower capability of obtaining the substance could partly explain this relationship. Perhaps because patients with social wit...Continue Reading

References

Jan 11, 1990·Schizophrenia Bulletin·M B BowersP I Jatlow
Nov 1, 1985·The American Journal of Psychiatry·E J Khantzian
Mar 1, 1995·The American Journal of Psychiatry·L DixonA Lehman
Feb 1, 1994·The Journal of Nervous and Mental Disease·P LysakerR Milstein
May 1, 1996·Schizophrenia Research·C D SwoffordL B Inderbitzin
Feb 24, 2001·American Journal of Public Health·S D RosenbergM P Salyers
Jun 4, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Elizabeth WalshThomas Fahy
Jul 5, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Keith HawtonJonathan J Deeks
Jul 5, 2005·Nature Reviews. Genetics·David GoldmanFrancesca Ducci
Mar 16, 2006·Psychological Medicine·Stéphane PotvinEmmanuel Stip
Jun 6, 2006·Schizophrenia Research·A TalamoR J Baldessarini
Aug 6, 2010·The American Journal of Psychiatry·Susanne WicksChristina Dalman
Mar 1, 2012·The Australian and New Zealand Journal of Psychiatry·Katherine MullinMatthew Large
Jan 3, 2014·JAMA Psychiatry·Sarah M HartzUNKNOWN Genomic Psychiatry Cohort Consortium
Jan 28, 2014·Psychiatry Research·Kim DonoghueJames H Maccabe
Feb 15, 2015·Social Psychiatry and Psychiatric Epidemiology·Ragnar NesvågTed Reichborn-Kjennerud

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