PMID: 11925304Apr 2, 2002Paper

Negative symptoms in temporal lobe epilepsy

The American Journal of Psychiatry
Kiesa GetzVince Magnotta

Abstract

This study examined the frequency of negative and positive symptoms in nonpsychotic patients with temporal lobe epilepsy and the relationship of negative and positive symptoms to cognition, quantitative magnetic resonance imaging (MRI) volumetrics, and depression. Eighty-four patients with temporal lobe epilepsy and 74 healthy comparison subjects were evaluated for negative and positive symptoms and underwent comprehensive neuropsychological evaluation, quantitative MRI volumetrics, and assessment of mood state and depression. Negative symptoms were significantly more prevalent in the patients with temporal lobe epilepsy (31%) than in the comparison subjects (8%). There was no difference between groups in the rate of positive symptoms. Although the epilepsy patients as a group exhibited generalized cognitive impairment relative to the comparison subjects, the epilepsy patients with negative symptoms performed significantly worse than patients without negative symptoms and comparison subjects across measures of nonverbal intelligence, visuoperception, speeded visuomotor processing, and memory. The epilepsy patients with negative symptoms exhibited significantly greater diffuse atrophy than the healthy comparison subjects and hig...Continue Reading

Citations

Apr 16, 2003·Epilepsy Research·Kiesa GetzAustin Woodard
Nov 23, 2006·Nature Clinical Practice. Neurology·Andrew J Cole
Dec 6, 2007·Epilepsia·Siddhartha NadkarniOrrin Devinsky
Jul 23, 2009·The Journal of Neuropsychiatry and Clinical Neurosciences·Elizabeth K GearyBruce Hermann
Aug 31, 2012·Epilepsy Research and Treatment·Vadim Beletsky, Seyed M Mirsattari
Sep 23, 2014·Current Psychiatry Reports·Kamalika RoyB Harrison Levine
Apr 16, 2009·Neuroscience Research·Nicola G CascellaAkira Sawa
Sep 21, 2007·Epilepsy & Behavior : E&B·Leonhard SchilbachEva K Ritzl
May 9, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·F S BersaniM Biondi
Oct 4, 2017·Schizophrenia Bulletin·Gregory P Strauss, Alex S Cohen

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