Negative symptoms of schizophrenia: from electrophysiology to electrotherapy

L'Encéphale
J-A Micoulaud FranchiJ-M Azorin

Abstract

The aim of this review of the literature is to summarize the state of the knowledge concerning the relationship between negative symptoms in schizophrenia, electrophysiology and electrotherapy. The scientific literature search of international articles was performed during August and September 2015 using the PubMed electronic database. We used the following MeSH terms: "Negative symptoms", "Schizophrenia", "Electrophysiology", "Neurophysiology", "EEG power", "Alpha rhythm", "Transcranial magnetic stimulation", "Transcranial direct current stimulation", "Electroconvulsive therapy", "Neurofeedback", "Vagus Nerve Stimulation", "Deep Brain Stimulation", and "State dependent". Negative symptoms in schizophrenia are associated with altered activity in prefrontal cortex in functional neuroimaging studies. This is in line with electrophysiological measurements that found a change in EEG spectral power in the alpha frequency band over prefrontal brain regions. The notion of functional hypofrontality has led to hypotheses that electrotherapy applied to the prefrontal cortex may be an effective treatment of negative symptoms in schizophrenia. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (...Continue Reading

References

Jan 1, 1974·Acta Psychiatrica Scandinavica·D H Ingvar, G Franzén
May 1, 1996·Schizophrenia Research·E L Merrin, T C Floyd
Jan 23, 1999·Biological Psychiatry·L D Selemon, P S Goldman-Rakic
Sep 9, 2004·Acta Psychiatrica Scandinavica·K HillP J McKenna
Dec 17, 2004·Journal of Neurophysiology·Bernd FeigeErich Seifritz
May 26, 2007·NeuroImage·N OishiM Hallett
Mar 7, 2008·Acta Psychiatrica Scandinavica·Tom G Bolwig
Jul 19, 2008·Acta Psychiatrica Scandinavica·M G KnyazevaK Q Do
Sep 16, 2008·Brain Topography·Juha Silvanto, Alvaro Pascual-Leone
Apr 7, 2010·The Journal of Clinical Psychiatry·Jozarni J Dlabac-de LangeAndré Aleman
Jul 14, 2010·Neuroscience and Biobehavioral Reviews·Anne-Kathrin J FettLydia Krabbendam
May 15, 2012·The American Journal of Psychiatry·Jerome BrunelinEmmanuel Poulet
Sep 21, 2013·Frontiers in Human Neuroscience·Jean-Arthur Micoulaud-FranchiGuillaume Dumas
Sep 26, 2013·European Archives of Psychiatry and Clinical Neuroscience·Alkomiet HasanZafiris J Daskalakis
Jun 20, 2015·Current Pharmaceutical Design·Thomas FovetDavid Linden
Jul 19, 2015·Schizophrenia Research·Jozarni J Dlabac-de LangeAndré Aleman
Jul 27, 2015·European Archives of Psychiatry and Clinical Neuroscience·Alkomiet HasanThomas Wobrock
Aug 19, 2015·Brain Stimulation·July Silveira GomesQuirino Cordeiro

❮ Previous
Next ❯

Citations

Feb 29, 2020·Neuropsychiatric Disease and Treatment·Christoph U Correll, Nina R Schooler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.