Negative symptoms of schizophrenia: historical aspects

L'Encéphale
D PringueyJ-M Azorin

Abstract

The history of negative symptoms of schizophrenia rises early days of medicine in clinical and pathophysiological differences between positive and negative and their complex joint. Forming a set of typical core of symptoms, and some feature of a syndrome belonging to a specific pathophysiological mechanism, negative symptoms of schizophrenia emerge from old descriptions of clinical pictures, related to the overall look of madness, the heart of alienation, a central sign of early dementia, gradually more precisely describing the strange nature of the autistic withdrawal and schizophrenic apragmatism. At therapeutic era, negative symptoms have taken over the positive symptoms to establish an operational criteria whose importance lies in the progressive severity of this clinical type and in their contribution to therapeutic resistance. Despite the efforts of modern typological classifications, this work rehabilitates the old concept of "unitary psychosis" by defining a common symptomatic core to multiple clinical forms of psychosis, combining deficit of emotional expression and avolition, meaning a native psychopathology and a pathophysiology possibly in a common final way, and calling the arrival of new treatment strategies.

References

Feb 1, 1978·The American Journal of Psychiatry·R Abrams, M A Taylor
Oct 1, 1989·Archives of General Psychiatry·P E Meehl
Mar 1, 1966·The British Journal of Psychiatry : the Journal of Mental Science·J Chapman
Jul 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J M S Pearce
Feb 17, 2006·Schizophrenia Bulletin·Brian KirkpatrickStephen R Marder
Dec 10, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dolores MalaspinaFabien Trémeau
May 14, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mark J MillanWilliam P Horan
Jun 17, 2014·CNS Neuroscience & Therapeutics·Jean-Michel AzorinMarc Adida

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