Negative synergism of diabetes mellitus and obesity in patients with heart failure with preserved ejection fraction: a cardiovascular magnetic resonance study.

The International Journal of Cardiovascular Imaging
Selcuk KucukseymenReza Nezafat

Abstract

In patients with heart failure with preserved ejection fraction (HFpEF), diabetes mellitus (DM) and obesity are important comorbidities as well as major risk factors. Their conjoint impact on the myocardium provides insight into the HFpEF aetiology. We sought to investigate the association between obesity, DM, and their combined effect on alterations in the myocardial tissue in HFpEF patients. One hundred and sixty-two HFpEF patients (55 ± 12 years, 95 men) and 45 healthy subjects (53 ± 12 years, 27 men) were included. Patients were classified according to comorbidity prevalence (36 obese patients without DM, 53 diabetic patients without obesity, and 73 patients with both). Myocardial remodeling, fibrosis, and longitudinal contractility were quantified with cardiovascular magnetic resonance imaging using cine and myocardial native T1 images. Patients with DM and obesity had impaired global longitudinal strain (GLS) and increased myocardial native T1 compared to patients with only one comorbidity (DM + Obesity vs. DM and Obesity; GLS, - 15 ± 2.1 vs - 16.5 ± 2.4 and - 16.7 ± 2.2%; native T1, 1162 ± 37 vs 1129 ± 25 and 1069 ± 29 ms; P < 0.0001 for all). A negative synergistic effect of combined obesity and DM prevalence was observ...Continue Reading

References

Jul 21, 2005·JAMA : the Journal of the American Medical Association·Erik IngelssonLars Lind
Oct 12, 2005·Journal of Molecular and Cellular Cardiology·Alfred P McQueenSheldon E Litwin
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Jul 25, 2007·Circulation·Houman AshrafianLionel H Opie
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Feb 2, 2010·Journal of the American College of Cardiology·Tamara B Horwich, Gregg C Fonarow
Aug 22, 2013·Journal of the American Heart Association·Ravi V ShahMichael Jerosch-Herold
May 7, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sébastien RoujolReza Nezafat
Jun 3, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Vanessa M FerreiraStefan Neubauer
Aug 12, 2014·Journal of the American College of Cardiology·Brian R LindmanMargaret M Redfield
Aug 19, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sebastian WeingärtnerReza Nezafat
Sep 23, 2014·JACC. Cardiovascular Imaging·Mao-Yuan M SuWen-Yih I Tseng
Jan 27, 2016·Journal of the American Heart Association·Rohan SamsonThierry H Le Jemtel
Jul 9, 2016·Journal of the American College of Cardiology·Daniel DalosDiana Bonderman
Dec 3, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Philip HaafSven Plein
Aug 5, 2017·Frontiers in Endocrinology·Raffaele AltaraGeorge W Booz
Dec 2, 2017·Journal of the American College of Cardiology·Tetsuro Tsujimoto, Hiroshi Kajio
Jan 13, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Prathap KanagalaGerry P McCann
Mar 27, 2018·Journal of the American Heart Association·Nicholas CauwenberghsTatiana Kuznetsova
Jul 17, 2018·JACC. Heart Failure·Nazir SavjiJennifer E Ho
Nov 27, 2018·Lipids in Health and Disease·Ki-Bum WonHyuk-Jae Chang
Nov 28, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yanjie ZhuReza Nezafat
Dec 3, 2018·JACC. Heart Failure·Ambarish PandeyCarl J Lavie
Feb 9, 2019·Journal of the American College of Cardiology·Kelly McHughAdrian F Hernandez
Apr 22, 2019·JACC. Cardiovascular Imaging·Andreas A KammerlanderJulia Mascherbauer
Jul 17, 2019·Therapeutic Advances in Endocrinology and Metabolism·Gaurav S GulsinGerry P McCann

❮ Previous
Next ❯

Citations

Jun 18, 2021·Advanced Drug Delivery Reviews·Alexandros Marios SofiasTwan Lammers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.