Negativity for Specific Autoantibodies in Patients with Type 1 Diabetes That Developed on a Background of Common Variable Immunodeficiency

International Archives of Allergy and Immunology
Tomáš MilotaESID Registry Working Party

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous group of disorders characterized by disturbed antibody production and a dysregulated immune system. Aside from recurrent infections, the most common complications of CVID are autoimmune complications, particularly autoimmune cytopenias. To date, type 1 diabetes mellitus (T1D) in combination with CVID has only been described as an unusual complication in several reports, but the true incidence of T1D with CVID remains unknown. We describe 2 patients with a combination of T1D and CVID with serious impairment of antibody production. We also provide a review of the available literature. T1D-specific insulin autoantibodies and autoantibodies to glutamic acid decarboxylase and tyrosine phosphatase IA2 were not detected in either of our patients at the time of diagnosis or during the course of the disease. In both cases, T1D manifestation and diagnosis preceded the discovery of CVID by several years. Following the diagnosis of immunodeficiency and the start of immunoglobulin substitution therapy, their clinical status improved, manifesting as a lower frequency of infections and improved T1D control, with decreased glycosylated hemoglobin A1c values. Based on these reported cas...Continue Reading

Citations

Dec 26, 2016·International Archives of Allergy and Immunology·Gholamreza AziziAsghar Aghamohammadi
Mar 20, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Chenggui MiaoYanxi Fang
Mar 27, 2018·Scandinavian Journal of Immunology·G AziziA Aghamohammadi
May 31, 2018·The Journal of Clinical Endocrinology and Metabolism·Bruno HalpernMaria Adelaide Albergaria Pereira
Mar 14, 2021·Trends in Endocrinology and Metabolism : TEM·Shivani K PatelJerry R Greenfield

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