Neglected diseases caused by bacterial infections

Current Medicinal Chemistry
M BechtleT Efferth

Abstract

Bacterial infections represent a major health problem, especially in third world countries. In endemic regions, large populations of people are greatly affected, but the medical care is very limited. In this review, the neglected diseases buruli ulcer and trachoma are elucidated. Buruli ulcer is caused by Mycobacterium ulcerans which produces an outstanding immunosuppressive toxin mycolactone that induces an ulcerative, necrotic skin disease. Until today, only the combination of rifampin/streptomycin is used to treat buruli ulcer. However, this therapy is ineffective and expensive. Here, we report new findings that suggest pharmaceutical formulations such as rifapentine, in combination with clarithromycin or moxifloxacin that have shown promising results in mice footpad trials. Moreover, alternative treatment options such as heat therapy, nitric oxide cremes and French clay show bactericidal effects. The genotyping of M. ulcerans also promises new ways of finding drug targets and vaccines. Trachoma, induced by the bacterium Chlamydia trachomatis, is the primary infectious cause of blindness worldwide. Recurrent infections lead to chronic inflammation of the upper tarsal conjunctiva. As a consequence, scarring and distortion of ...Continue Reading

Citations

Sep 25, 2012·Journal of Materials Science. Materials in Medicine·Rachna N DaveVayalam P Venugopalan
Aug 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angélique LewiesDu Plessis Lissinda Hester
Feb 3, 2016·BMC Complementary and Alternative Medicine·Sarojini Adusumilli, Shelley E Haydel
Sep 14, 2010·Microbes and Infection·Denise BambergerThomas Efferth
Mar 11, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Amanda Mara TelesFernando Almeida-Souza

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