Neighbor of Punc E11, a novel oncofetal marker for hepatocellular carcinoma.

International Journal of Cancer. Journal International Du Cancer
Jens Uwe MarquardtDirk Nierhoff

Abstract

Hepatocellular carcinoma (HCC) is the 5th common malignancy worldwide, but established markers fail to detect up to one third of HCC. We have recently identified Neighbor of Punc E11 (Nope) as a surface marker for murine fetal liver stem cells. Similar to commonly used HCC markers such as α-Fetoprotein (Afp) and Glypican-3 (Gpc-3), we here establish Nope as an oncofetal marker of murine and human HCC and investigate its specific expression in hepatoma cell lines and primary HCC. Murine and human hepatoma cell lines and Cre-inducible SV40 T-antigen transgenic mice (Alb-SV40TAg(ind) ) were analyzed for Nope expression in comparison to common HCC markers by quantitative RT-PCR, Western blot analyses and immunohistochemistry. Nope expression in primary human HCC was investigated using Oncomine Microarray database. Nope expression was elevated in 8 of 10 investigated murine and human hepatoma cell lines and in all tumors of our oncogenic mouse model but remained undetectable in normal liver and at preneoplastic stages of murine hepatocarcinogenesis. Furthermore, a significant induction of Nope was detected in primary human cancers compared to corresponding normal or cirrhotic tissue. Nope expression in tumor specimens and murine cel...Continue Reading

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Citations

Jan 6, 2012·Annals of Surgical Oncology·Lichao SunYuliang Ran
Apr 20, 2017·International Journal of Molecular Sciences·Anke SchmidtSander Bekeschus
Jan 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Suxia JiangLinqiang Pan
Apr 7, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Andrea BoweDirk Nierhoff
Sep 29, 2020·Cancer Biomarkers : Section a of Disease Markers·Susanne ZweerinkDirk Nierhoff

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