Neisseria gonorrhoeae and Chlamydia trachomatis infection in HIV-1-infected women taking antiretroviral therapy: a prospective cohort study from Burkina Faso

Sexually Transmitted Infections
Andrea J LowYerelon Cohort study group

Abstract

Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) are common sexually transmitted infections (STI). We assessed the cumulative risk of NG and CT in a cohort of HIV-1-infected high-risk women taking antiretrovirals over 4 years in Burkina Faso. Between March 2007 and February 2011, participants were followed every 3-6 months. At each visit, participants underwent a gynaecological examination with collection of cervical and vaginal swabs. Random-effects logistic regression models were used to analyse associations of NG and CT infection with behavioural and biological factors. 172 women had samples tested for NG and CT during the study period, in a total of 1135 visits. NG was detected in 6.4% of women (11/172, 95% CI 2.7 to 10.1) at a rate of 2.76 cases (95% CI 1.53 to 4.99) per 100 person-years. CT was detected in 1.7% (3/172, 95% CI 0 to 3.7) of women at a rate of 0.75 cases (95% CI 0.24 to 2.34) per 100 person-years. The majority of women were asymptomatic (9/14). In the multivariable model, the presence of NG or CT was associated with tobacco use (aOR=11.85, 95% CI 1.13 to 124.17), and concurrent genital HIV-1 RNA shedding (aOR=4.78, 95% CI 1.17 to 19.46). Higher levels of education (aOR=0.17, 95% CI 0.03 to 0.92), an...Continue Reading

References

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Citations

Dec 17, 2014·Scientific Reports·Young-Jo LeeJong-Yoon Chun
Mar 1, 2018·International Journal of STD & AIDS·Jan Henk DubbinkRemco Ph Peters
Sep 2, 2014·Expert Review of Anti-infective Therapy·Elisa MountainMarie-Claude Boily
Aug 12, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Putu DuffKate Shannon
May 12, 2015·HIV Medicine·A CingolaniUNKNOWN Community-Oriented Study Group of the Icona Foundation Study Group
May 20, 2021·MBio·Hannah M Rowe, Jason W Rosch

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Methods Mentioned

BETA
PCR
lavage

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