PMID: 109025Jun 1, 1979

Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency

Annals of Internal Medicine
B H PetersenG F Brooks


We summarize data from 24 previously described or newly diagnosed cases of homozygous deficiency of the sixth, seventh, or eighth components of complement. Thirteen of 24 patients had at least one episode, and usually two or more episodes of Neisseria meningitidis or Neisseria gonorrhoeae bacteremia, or both. Deficiency of C6, C7, or C8 is a meaningful risk factor for repeated neisserial bacteremia; conversely, hemolytic complement studies are indicated in patients who develop recurrent neisserial infections. When a person with C6, C7, or C8 deficiency is identified, family members should also be studied.


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Related Concepts

Complement component C6
Complement component C7
Complement Component C8 gamma
Immunologic Deficiency Syndromes
Meningococcal Infections
Neisseria gonorrhoeae
Neisseria meningitidis

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