Neisseria meningitidis Isolated in Postmortem Vitreous Humor in a Death Due to Meningococcal Sepsis

The American Journal of Forensic Medicine and Pathology
Jack GarlandAllan D Cala

Abstract

Sepsis remains a difficult diagnosis at autopsy. With respect to meningococcal sepsis, a timely and definite diagnosis is critical because it requires public health department notification and the administration of prophylactic antibiotics to potential close contacts. A previous case series, in which both blood and cerebrospinal fluid were unavailable, suggested vitreous humor polymerase chain reaction might be a useful test in diagnosing meningococcal sepsis. We describe a fatal case of meningococcal sepsis where Neisseria meningitidis was detected in both vitreous humor and blood polymerase chain reaction, in addition to positive blood cultures. This gives further support to using microbiology of vitreous humor in suspected meningococcal sepsis, especially when microbiology samples are limited.

References

Jun 1, 1993·The American Journal of Forensic Medicine and Pathology·J I Coe
Jan 11, 2000·Clinical Microbiology Reviews·M van DeurenJ W van der Meer
Jul 31, 2003·Journal of Paediatrics and Child Health·W L YeungJ Hui
Jul 6, 2004·Ophthalmology·David N Zacks
Mar 16, 2005·Journal of Cataract and Refractive Surgery·Elizabeth ChackoPatrick I Condon
May 10, 2005·Diagnostic Microbiology and Infectious Disease·Marie-Cécile PloyFrançois Denis
Jan 6, 2006·Journal of Clinical Pathology·J A MorrisS M Partridge
Jun 22, 2006·Forensic Science International : Synergy·Michael Tsokos
Apr 5, 2013·Journal of Forensic Sciences·Géraldine MaujeanDaniel Malicier
Jan 10, 2014·Journal of Clinical Microbiology·Stefan Riedel
Feb 26, 2014·Emerging Infectious Diseases·Alison D RidpathDon Weiss
Jan 28, 2015·Journal of Forensic and Legal Medicine·Cristian PalmiereLuca Reggiani Bonetti

Citations

Nov 27, 2018·The American Journal of Forensic Medicine and Pathology·Jack GarlandRexson Tse
Jan 22, 2019·The American Journal of Forensic Medicine and Pathology·Sarah Hensby-BennettRexson Tse

Related Concepts

Meningococcal Infections
Neisseria meningitidis
Pregnancy Complications, Infectious
Vitreous Body Structure
Fatal Outcome
Pyemia
Antibiotics
Autopsy
Blood
Cerebrospinal Fluid

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