PMID: 8614064May 1, 1996Paper

Neither dopamine nor dobutamine reverses the depression in mesenteric blood flow caused by positive end-expiratory pressure

The Journal of Trauma
G AzarS Steinberg

Abstract

Positive end-expiratory pressure (PEEP) has been shown to cause a depression of mesenteric blood flow (MBF) and redistribution of blood flow away from the mesenteric vascular bed. We sought to determine whether two commonly used vasoactive agents, dopamine, a known mesenteric vasodilator and inotrope, and dobutamine, with its inotropic properties, would correct the MBF depression caused by PEEP. DESIGN, MATERIAL, AND METHODS: Sprague-Dawley rats, 180 to 250 g, were treated with mechanical ventilation and either no PEEP (control group) or increasing levels (0, 10, 15, and 20 cm of H2O pressure) of PEEP (PEEP group). Also, we evaluated PEEP's effect on MBF and cardiac output (CO) under the influence of a continuous infusion of 2.5 or 12.5 microgram/kg/min of dopamine or 2.5 or 12.5 microgram/kg/min of dobutamine. Cardiac output and, using in vivo videomicroscopy, mesenteric A1, A2, and A3 arteriolar intraluminal radii and A1 arteriolar optical Doppler velocities were measured. After 20 cm of H2O pressure PEEP was attained, two boluses of 2 mL of 0.9 normal saline were given. The MBF was calculated from vessel radius and red blood cell velocity. There were no significant changes from baseline in mean arterial pressure or A2 or A3 ...Continue Reading

References

Apr 11, 1991·The Journal of Surgical Research·D J JohnsonJ M Hurst
Feb 1, 1991·Journal of Applied Physiology·C RisöeO A Smiseth
Sep 1, 1989·British Journal of Pharmacology·J C Wanstall, S R O'Donnell
Jul 1, 1988·The Journal of Trauma·J W BakerR D Specian
May 1, 1993·Acta Anaesthesiologica Scandinavica·Y Fujita

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