PMID: 8597777Nov 24, 1995Paper

Neither dosage nor serum levels of antiepileptic drugs are predictive for efficacy and adverse effects

Pharmacy World & Science : PWS
M W LammersW O Renier

Abstract

In order to assess whether doses or serum levels are predictive for the efficacy and adverse effects of antiepileptic drugs (AEDs), measures for exposure to drug combinations have to be used. For doses, the ratio of the observed prescribed daily dose (PDD) and the average defined daily dose (DDD) considered effective for the main indication of the drug was used. In analogy for serum levels, the OSL/ATL ratio, i.e. the ratio of the observed serum level and the average therapeutic level was used. In polypharmacy these ratios can be summed as the are normalized measures of strength. The correlations of these ratios with outcome measures were studied in 200 patients attending out-patient clinics of special centres for epilepsy; half of these patients were treated with monopharmacy and half with polypharmacy. As outcome measures the following indices were used: the index of seizures, which quantifies seizure type and frequency, the seizure activity index, the neurotoxicity score, the systemic toxicity score, and the composite index of impairments, which is the sum of the seizure activity index and the neurotoxicity score and the systemic toxicity score. When all data were pooled, the correlation coefficient between the PDD/DDD ratio...Continue Reading

References

Aug 23, 1991·Pharmaceutisch Weekblad. Scientific Edition·D J WijsmanH Meinardi
Apr 1, 1984·Drugs·M J Eadie
Nov 1, 1980·Pediatric Clinics of North America·C E Pippenger
Jun 1, 1994·Acta Neurologica Scandinavica·M W LammersH van Lier
Jun 1, 1993·Acta Neurologica Scandinavica·D J WijsmanH van Lier

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Citations

Oct 9, 2002·European Journal of Drug Metabolism and Pharmacokinetics·Graciela N Balerio, Modesto C Rubio
Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·M K BanksP E Garraghty
Jan 12, 1999·Neuroscience and Biobehavioral Reviews·O E Della PaschoaM Danhof
May 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·M K BanksP E Garraghty
Dec 1, 1996·Acta Neurologica Scandinavica·J Bauer
Apr 1, 1997·Acta Neurologica Scandinavica·C L DeckersW O Renier
Mar 24, 1998·Annual Review of Medicine·C W Bazil, T A Pedley
Jul 29, 2008·Epilepsy & Behavior : E&B·Kim B HandokoToine C G Egberts
Mar 4, 2017·International Journal of Clinical Pharmacy·László HorváthIstván Fekete
Aug 29, 2018·CNS Drugs·Yvonne HöllerKlaus Lehnertz

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