Nematode infection in Alymphoplasia (aly) mice: worm species-dependent differential effect of defects of the gut-associated lymphatic tissue system

Scandinavian Journal of Immunology
M MorimotoT Hayashi

Abstract

Mice homologous for the alymphoplasia mutation (aly) show the systemic absence of secondary lymphoid tissues, with disorganized splenic architecture, including the absence of the germinal centre and follicular dendritic cells. In this study, we examined the influence of defects of gut-associated lymphoid tissue (GALT), such as Peyer's patches and the mesenteric lymph nodes, on the host response to helminth infection in aly/aly mice. The present study showed that most of the worms were expelled by day 7 after Nippostrongylus brasiliensis infection in both control aly/+ and aly/aly mice. In aly/aly mice, the number of peripheral blood eosinophils, intestinal goblet cells and mucosal mast cells were increased by N. brasiliensis infection in aly/aly mice to the same level as in the controls. Conversely, aly/aly mice developed more severe Heligmosomoides polygyrus infections than control aly/+ mice, as demonstrated by increased faecal egg counts, with reduced immune responses such as the numbers of intestinal goblet cells and mucosal mast cells. These results suggested that the dependency of GALT in activation of Th2 responses against gastrointestinal nematodes was different depending on the species of nematode.

References

Jan 1, 1982·International Archives of Allergy and Applied Immunology·R V HeatleyJ Bienenstock
Jul 1, 1994·Parasite Immunology·Y NawaF Uchiyama
Jan 1, 1997·Annual Review of Immunology·S L Constant, K Bottomly
Mar 25, 1998·Current Biology : CB·G J McKenzieA N McKenzie
May 7, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G HalldénJ Lundahl
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motoko MorimotoWilliam C Gause
Sep 14, 2004·Immunological Reviews·Fred D FinkelmanJoseph F Urban
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katja MohrsMarkus Mohrs

❮ Previous
Next ❯

Citations

Nov 6, 2018·The Journal of Veterinary Medical Science·Afia KhatunMasahiro Morimoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.