Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks

Organic Letters
Joshua J YimFrank C Schroeder

Abstract

In the nematode model organisms Caenorhabditis elegans and Pristionchus pacificus, a new class of natural products based on modular assembly of primary-metabolism-derived building blocks control organismal development and behavior. We report identification and biological activities of the first pentamodular metabolite, pasa#9, and the 8-oxoadenine-containing npar#3 from P. pacificus. These structures suggest co-option of nucleoside and tryptophan metabolic pathways for the biosynthesis of endogenous metabolite libraries that transcend the dichotomy between "primary" and "secondary" metabolism.

References

Aug 19, 2004·Journal of the American Chemical Society·Andrew E TaggiFrank C Schroeder
Nov 9, 2007·WormBook : the Online Review of C. Elegans Biology·Lindy Holden-Dye, Robert J Walker
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chirag PungaliyaFrank C Schroeder
Nov 27, 2009·Accounts of Chemical Research·Sriram KanvahUzi Landman
Dec 8, 2009·Science·Akira Ogawa, Ralf J Sommer
Nov 13, 2010·Current Opinion in Chemical Biology·Ry R Forseth, Frank C Schroeder
Jan 14, 2012·Journal of the American Chemical Society·Stephan H von ReussFrank C Schroeder
Mar 2, 2012·The Journal of Biological Chemistry·Christopher DeutschDirk Iwata-Reuyl
Apr 17, 2012·Current Biology : CB·Andrea ChoePaul W Sternberg
Apr 17, 2012·PLoS Biology·Siu Sylvia Lee, Frank C Schroeder
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Donha ParkDonald L Riddle
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Annemieke T van der GootEllen A A Nollen
Nov 20, 2012·Angewandte Chemie·Neelanjan BoseFrank C Schroeder
Jan 29, 2013·WormBook : the Online Review of C. Elegans Biology·Andreas H Ludewig, Frank C Schroeder
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andreas H LudewigFrank C Schroeder
May 22, 2013·The Journal of Biological Chemistry·Alexander B ArtyukhinFrank C Schroeder

❮ Previous
Next ❯

Citations

May 18, 2016·Molecular Biology and Evolution·Gabriel V MarkovRalf J Sommer
Apr 8, 2017·Natural Product Reports·Rebecca A Butcher
May 18, 2017·Nature Chemical Biology·Rebecca A Butcher
Jun 11, 2015·Natural Product Reports·Stephan H von Reuss, Frank C Schroeder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.