NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?

Biochemical and Biophysical Research Communications
Antero SalminenKai Kaarniranta

Abstract

Activation of NF-kappaB transcription factor signaling is one of the hallmarks of genotoxic stress. Recently, the NEMO shuttle was revealed to mediate this nucleo-cytoplasmic signaling linking DNA damage to the activation of NF-kappaB system. DNA damage is the causative factor of several segmental progeroid syndromes, such as Werner syndrome and Hutchinson-Gilford syndrome. Although the gene defects have been well characterized, the molecular mechanisms of premature aging process still need to be defined. Here we review the details of the NEMO shuttle, a dual-signal sensor linking DNA damage to NF-kappaB activation, and present evidence for the hypothesis that DNA damage in progeroid syndromes may activate the NEMO shuttle and subsequently increase the pressure on the activation of NF-kappaB system evoking a premature aging phenotype. The NEMO shuttle may link genotoxic stress to the activation of the innate immunity system and cause premature aging via inflamm-aging process.

References

Jan 1, 1992·Free Radical Research Communications·R SchreckP A Baeuerle
Apr 12, 1996·Science·C E YuG D Schellenberg
Mar 17, 2000·Immunological Reviews·R Medzhitov, C Janeway
Oct 29, 2000·Experimental Gerontology·C FranceschiG De Benedictis
Nov 13, 2002·Mutation Research·Larry H Thompson, David Schild
Jun 14, 2003·The Biochemical Journal·Csanád Z Bachrati, Ian D Hickson
Jun 11, 2004·Annual Review of Biochemistry·Aziz SancarStuart Linn
Sep 9, 2004·Science·David KiplingRichard G A Faragher
Oct 14, 2004·Cell·Dongsheng CaiSteven E Shoelson
Mar 4, 2005·The International Journal of Biochemistry & Cell Biology·Monika Puzianowska-Kuznicka, Jacek Kuznicki
Sep 22, 2005·Nature Reviews. Immunology·Michael Karin, Florian R Greten
Nov 30, 2005·Immunological Reviews·Jackie A ClowesSundeep Khosla
Dec 20, 2005·Cell·Sophie JanssensJürg Tschopp
Jan 18, 2006·Cell Death and Differentiation·S Janssens, J Tschopp
Jun 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dale K ShumakerRobert D Goldman
Jun 15, 2006·Journal of Cell Science·Kaliyaperumal ManjuVeena K Parnaik
Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Valérie SchreiberGilbert de Murcia
Aug 15, 2006·Nature Cell Biology·Angela M MabbShigeki Miyamoto
Sep 13, 2006·Biochemical Pharmacology·Yvette Habraken, Jacques Piette
Sep 22, 2006·Trends in Cell Biology·Hélène SebbanGilles Courtois
Sep 22, 2006·Human Molecular Genetics·Claire L NavarroNicolas Lévy
Nov 9, 2006·Free Radical Research·Alexander Bürkle
Dec 2, 2006·Nature Reviews. Genetics·Brian C Capell, Francis S Collins
May 29, 2007·Cellular and Molecular Life Sciences : CMLS·A M Mabb, S Miyamoto

❮ Previous
Next ❯

Citations

May 2, 2009·Journal of Clinical Immunology·Antero Salminen, Kai Kaarniranta
Dec 29, 2010·Cell Research·Shigeki Miyamoto
Sep 13, 2011·Nucleic Acids Research·Meta VolcicLisa Wiesmüller
Jun 22, 2013·Immunity & Ageing : I & a·Carmela R BalistreriDomenico Lio
Nov 12, 2009·Ageing Research Reviews·Antero Salminen, Kai Kaarniranta
Apr 22, 2009·Trends in Molecular Medicine·Antero Salminen, Kai Kaarniranta
Dec 6, 2017·PLoS Computational Biology·Patrick MeyerKarin Scharffetter-Kochanek
Nov 17, 2019·Cells·Christian SchmeerOtto W Witte
Feb 16, 2020·International Journal of Molecular Sciences·Yongfeng Li, Francis A Cucinotta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.