Abstract
Osteomyelitis, which is characterized by progressive inflammatory bone destruction and resorption, is a difficult‑to‑treat infection. Staphylococcus aureus (S. aureus) is one of the major causes of this disease. This pathogenic microorganism possesses several characteristics, which facilitate its involvement in the occurrence and progression of osteomyelitis. A cell‑permeable peptide inhibitor of the IκB kinase complex, the nuclear factor (NF)‑κB essential modulator‑binding domain (NBD) peptide, has been reported to block osteoclastogenesis and may be considered a potential strategy for preventing inflammatory bone resorption. However, it remains to be determined as to whether the NBD peptide can regulate inflammation and bone resorption in S. aureus‑induced osteomyelitis. In order to investigate the role of NBD in S. aureus‑induced osteomyelitis, the present study obtained the NBD peptide, and confirmed that it inhibited receptor activator of NF‑κB ligand‑induced osteoclastogenesis in vitro. Subsequently, a bone defect was generated and S. aureus was injected into the mandible of experimental animals, in order to establish an in vivo osteomyelitis model. The present study analyzed the following three experimental groups: Untre...Continue Reading
References
Sep 1, 2000·Science·M J MayS Ghosh
Sep 19, 2002·The Journal of Biological Chemistry·Hitoshi HotokezakaKoji Nakayama
Sep 24, 2002·The Journal of Biological Chemistry·Michael J MaySankar Ghosh
May 25, 2004·Nature Medicine·Eijiro JimiSankar Ghosh
Jun 24, 2004·Journal of Periodontology·Andrés R SánchezAmy Weaver
Jul 15, 2004·The Journal of Biological Chemistry·Simon DaiYousef Abu-Amer
Jan 18, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Guillermo E ChaconF Michael Beck
Oct 14, 2006·Annals of the Rheumatic Diseases·I Strickland, S Ghosh
Nov 13, 2007·Nature Medicine·Rong WangMichael Otto
Dec 3, 2008·Cytokine & Growth Factor Reviews·Jiake XuRen Xiang Tan
Nov 3, 2009·Bone·Margareta VerdrenghAndrej Tarkowski
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Andrea Oeckinghaus, Sankar Ghosh
May 22, 2010·Biomaterials·Joshua S MoskowitzPaula T Hammond
Dec 17, 2011·Academic Radiology·Patric KröpilMohssen Hakimi
Feb 1, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C ZuoX Zhang
Jan 31, 2013·World Journal of Orthopedics·Lianping XingBrendan F Boyce
Feb 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu WangDana T Graves
Mar 5, 2015·Methods in Molecular Biology·Gaurav Swarnkar, Yousef Abu-Amer
Jan 3, 2016·Biomaterials·Jason A InzanaHani A Awad
Mar 5, 2016·Seminars in Immunology·George HajishengallisTriantafyllos Chavakis
Feb 12, 2017·Journal of Cellular Physiology·Yuan WangJun Fei
Mar 25, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ok-Jin ParkSeung Hyun Han
Jun 8, 2017·Journal of Translational Medicine·Christian GrossFalk Wehrhan
Nov 21, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Valerie AuroreMichael Walch
Apr 11, 2018·Cancer Cell·Maria KleppeRoss L Levine