Neo-clerodane diterpenes from Salvia herbacea

Journal of Natural Products
Elihú BautistaA Ortega

Abstract

Chemical investigation of the aerial parts of Salvia herbacea led to the isolation of eight new neo-clerodane diterpenes (1-8), named tehuanins A-H, and three known compounds. The structures of these compounds were determined by analysis of their spectroscopic data. Three of the new diterpenes possess a 1,8-epoxy group (1-3). This unusual structural feature was confirmed by X-ray diffraction of 1. The structure of the previously isolated 1α,10α-epoxysalviarin was revised. The absolute configuration of 6 was established by X-ray diffraction analysis of its bromo derivative 6a. Cytotoxic and anti-inflammatory activities of these diterpenes were examined. None of the compounds were considered to be cytotoxic; however, compound 7 exhibited anti-inflammatory activity comparable to that of indomethacin.

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Citations

Oct 9, 2013·Journal of Natural Products·Elihú BautistaAlfredo Ortega
Oct 30, 2016·Journal of Natural Products·Emma MaldonadoSimón Hernández-Ortega
Feb 2, 2017·Pharmaceutical Biology·Marco Martin González-ChávezRoberto Martínez
Jul 31, 2014·Journal of Natural Products·Tamara VasiljevikThomas E Prisinzano
Jul 20, 2016·Natural Product Reports·Rongtao LiKuo-Hsiung Lee
Jan 27, 2019·Pest Management Science·Francisco A MacíasJosé Mg Molinillo
Aug 15, 2013·Natural Product Reports·James R Hanson
Oct 10, 2019·Natural Product Research·Fei LiWei Zheng
Dec 11, 2020·Chinese Medicine·Zheling FengLigen Lin
Mar 15, 2014·Journal of Natural Products·Elihú BautistaAlfredo Ortega
Oct 7, 2014·Journal of Natural Products·Jing XuYuanqiang Guo
Jul 1, 2020·Journal of Natural Products·José Rivera-ChávezPatricia Cano-Sánchez

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