neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

Journal of Natural Products
Eung Tae YeonBang Yeon Hwang

Abstract

Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 μM.

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Citations

May 31, 2016·European Journal of Medicinal Chemistry·Gui-Min XueLing-Yi Kong
Jul 29, 2016·Natural Product Reports·James R Hanson
Nov 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huabei ZhangLuqi Huang
Jul 31, 2019·Natural Product Research·Jie ZhouZhi Zeng
Nov 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andreza Barbosa Silva CavalcantiMarcus Tullius Scotti
Dec 11, 2020·Chinese Medicine·Zheling FengLigen Lin
Aug 1, 2021·Phytochemistry·Yan-Gang CaoWei-Sheng Feng
Mar 27, 2020·Journal of Natural Products·Khan Viet NguyenHoai Thi Nguyen

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