Neoadjuvant and adjuvant strategies in retroperitoneal sarcoma

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
L Max AlmondAnant Desai

Abstract

Extended surgery remains the mainstay of treatment in retroperitoneal sarcoma, although conflicting data exist on the benefit of neoadjuvant and adjuvant therapies, particularly with regard to tumour grade and histological type. Experience of radiotherapy and chemotherapy in extremity soft tissue sarcoma can inform treatment strategies, however these data cannot be universally extrapolated to the retroperitoneum where disease biology and anatomical considerations are different. The present review sets a historical context before discussing recent evidence and on-going multi-centre trials in retroperitoneal sarcoma. Promising data on histologically- and molecularly-targeted chemotherapy are discussed and the need for centralisation of retroperitoneal sarcoma services in order to facilitate large international collaborative trials is emphasised.

Citations

Dec 18, 2019·Journal of Surgical Oncology·Elliot A AsareBarry W Feig
Jul 19, 2018·ESMO Open·Anna Maria FrezzaPaolo G Casali
Jul 16, 2020·Journal of Surgical Oncology·Pauliina HomsyCarl Blomqvist
May 14, 2020·The Surgical Clinics of North America·Michael K Turgeon, Kenneth Cardona
Apr 15, 2021·Annals of Surgical Oncology·Carol J SwallowUNKNOWN Transatlantic Australasian RPS Working Group (TARPSWG)
Dec 23, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·T MurezA Méjean
May 14, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Franziska WillisMartin Schneider
Oct 9, 2021·Radiation Oncology·Xiangji LiChenghua Luo

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