Neoadjuvant cetuximab, twice-weekly gemcitabine, and intensity-modulated radiotherapy (IMRT) in patients with pancreatic adenocarcinoma.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
J M PipasRichard J Barth

Abstract

Neoadjuvant therapy has been investigated for localized and locally advanced pancreatic ductal adenocarcinoma (PDAC) but no standard of care exists. Combination cetuximab/gemcitabine/radiotherapy demonstrates encouraging preclinical activity in PDAC. We investigated cetuximab with twice-weekly gemcitabine and intensity-modulated radiotherapy (IMRT) as neoadjuvant therapy in patients with localized or locally advanced PDAC. Treatment consisted of cetuximab load at 400 mg/m(2) followed by cetuximab 250 mg/m(2) weekly and gemcitabine 50 mg/m(2) twice-weekly given concurrently with IMRT to 54 Gy. Following therapy, patients were considered for resection. Thirty-seven patients were enrolled with 33 assessable for response. Ten patients (30%) manifested partial response and 20 (61%) manifested stable disease by RECIST. Twenty-five patients (76%) underwent resection, including 18/23 previously borderline and 3/6 previously unresectable tumors. Twenty-three (92%) of these had negative surgical margins. Pathology revealed that 24% of resected tumors had grade III/IV tumor kill, including two pathological complete responses (8%). Median survival was 24.3 months in resected patients. Outcome did not vary by epidermal growth factor recepto...Continue Reading

References

Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·J M PipasR P Perez
Apr 11, 2002·Nature Cell Biology·Martin A Schwartz, Mark H Ginsberg
Nov 7, 2002·International Journal of Radiation Oncology, Biology, Physics·Donald J BuchsbaumKevin P Raisch
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Ke LiangZhen Fan
Mar 23, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam C BergerMelvyn Goldberg
Dec 24, 2005·Annals of Surgical Oncology·Tsung-Yen ChengDouglas S Tyler
Mar 1, 2008·Journal of the American College of Surgeons·Sarah E GreerRichard J Barth
Jul 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lance Armstrong
Jul 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michele M CorsiniLeonard L Gunderson
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meredith A MorganTheodore S Lawrence
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meredith A MorganTheodore S Lawrence
Dec 30, 2009·Cancer Biology & Therapy·Jonah D Klein, Jennifer R Grandis
Mar 18, 2010·Cancer Biology & Therapy·Meir Preis, Murray Korc
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup

❮ Previous
Next ❯

Citations

Apr 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·John M StrotherRobert Dreicer
Mar 1, 2016·Current Problems in Surgery·Mariam F EskanderJennifer F Tseng
Aug 21, 2013·Journal of Surgical Oncology·Brian A BooneNathan Bahary
Mar 15, 2015·Cancer Medicine·Neelam V DesaiThomas J George
Mar 8, 2014·Oncoimmunology·Erika VacchelliLorenzo Galluzzi
Dec 17, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Martin-Immanuel BittnerThomas B Brunner
Dec 3, 2014·Seminars in Oncology·Darshil T JhaveriElizabeth M Jaffee
Oct 26, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jordan M CloydJeffrey E Lee
Jul 2, 2016·Therapeutic Advances in Gastroenterology·Suzanne Russo, M Wasif Saif
Nov 18, 2014·World Journal of Gastroenterology : WJG·Jeffrey M Sutton, Daniel E Abbott
Apr 8, 2020·Annals of Gastroenterological Surgery·Fuyuhiko Motoi, Michiaki Unno
Feb 18, 2016·Future Oncology·Suzanne RussoJennifer Dorth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.