Neoadjuvant chemoradiation changes podoplanin expression in esophageal cancer patients.

World Journal of Gastroenterology : WJG
Ute Warnecke-EberzElfriede Bollschweiler

Abstract

Locally advanced adenocarcinoma of the esophagus (EAC) and squamous cell carcinoma (ESCC) result in a worse prognosis. Neoadjuvant treatment improves survival, however, only for responders. The transmembrane glycoprotein podoplanin is overexpressed in squamous cell carcinomas, miRNA-363 is associated to its regulation in head and neck cancer. To predict therapy response and prognosis markers, and targets for novel therapies would individualize treatments leading to more favourable outcomes. Expression of podoplanin protein has been visualized by immunohistochemistry in surgical specimens of 195 esophageal cancer patients who underwent transthoracic esophagectomy: 90 ESCC and 105 EAC with clinical T2-3, Nx, M0. One hundred and six patients received neoadjuvant chemoradiation. RNA was extracted from paraffin-embedded tissue, and miRNA-363 quantified by real-time TaqMan-real-time-PCR. D2-40 mab staining of > 5% was scored as high podoplanin expression (HPE). We related podoplanin and miRNA-363 expression to histopathologic response after neoadjuvant treatment and clinicopathological characteristics, such as histological tumor type, survival rate or clinical tumor category. We confirmed expression of membrane-bound podoplanin in 90...Continue Reading

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Methods Mentioned

BETA
biopsies
PCR

Software Mentioned

MedCalc
SPSS

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