Neoadjuvant chemoradiation in patients with potentially resectable pancreatic cancer

Pancreas
Soichiro TakaiYasuo Kamiyama

Abstract

To retrospectively evaluate the efficacy and tolerability of 5-fluorouracil and low-dose cisplatin (FP)-based preoperative concurrent chemoradiotherapy (PCRT) and gemcitabine (GEM)-based PCRT in patients with potentially resectable pancreatic cancer. Between December 2000 and December 2004, 32 patients with potentially resectable pancreatic cancer were treated with PCRT. All patients received external beam radiotherapy (total dose of 40 Gy) for 4 weeks. Concurrently, chemotherapy was performed intravenously with continuous 5-fluorouracil 200 mg/m2/d and intermittent cisplatin bolus 3 to 6 mg/m2/d for 4 weeks (Arm FP-PCRT, n = 14) or weekly GEM 400 mg/m2 for 3 weeks (Arm GEM-PCRT, n = 18). The patients were restaged 3 to 4 weeks after the end of PCRT and explored for resection in cases without distant metastases. The 3-year survival rates and median survival were 29.4% and 20.5 months for the resected patients (n = 24) and 0% and 5.5 months for unresected patients (n = 8), respectively (P < 0.0001). The 1-, 2-, 3-year survival rates and median survival were 87.5%, 62.5%, 33.3%, and 26 months for the resected patients treated with FP-PCRT and 75%, 40%, 26.7%, and 19.9 months for the resected patients treated with GEM-PCRT (respec...Continue Reading

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K J ScanlonD G Priest
Apr 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P RougierJ P Armand
Oct 1, 1995·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M NicolsonT Hickish
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R SpitzD B Evans
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P HoffmanA B Benson
Dec 16, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W PistersD B Evans
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A W BlackstockJ E Tepper
Sep 19, 2001·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·C H CraneJ L Abbruzzese
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Christopher H CraneN A Janjan
Feb 11, 2003·American Journal of Clinical Oncology·Javier AristuIgnacio Azinovic
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Chung-Pin LiSang-Hue Yen
Aug 16, 2003·Journal of Hepato-biliary-pancreatic Surgery·Nicole M ChandlerMark P Callery
Jan 6, 2004·Annals of Surgery·Rebekah R WhiteDouglas S Tyler
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Ralf WilkowskiVolker Heinemann
Aug 4, 2004·American Journal of Clinical Oncology·Felipe A CalvoRafael Herranz
Jul 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yu Jo Chua, David Cunningham

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Citations

Dec 14, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sohei SatoiA-Hon Kwon
Mar 31, 2009·International Archives of Medicine·Doaa W MaximousAlaa A Abd-Elsayed
Mar 6, 2010·The Oncologist·Rajarshi Roy, Anthony Maraveyas
Sep 12, 2008·World Journal of Gastroenterology : WJG·Hisato IgarashiRyoichi Takayanagi
Feb 9, 2012·Journal of Surgical Oncology·Katia T PapalezovaRebekah R White
Feb 27, 2010·Journal of Surgical Oncology·Daniel E AbbottMark S Talamonti
Aug 15, 2009·Magyar sebészet·Attila Oláh
Mar 3, 2015·Seminars in Oncology·Megan WinnerJohn A Chabot
Aug 16, 2016·Advances in Surgery·Andrew P LoehrerCristina R Ferrone
Aug 30, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S W L de GeusJ F Tseng
Nov 29, 2012·The Cancer Journal·Stephanie L Goff, John A Chabot
Dec 14, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Susanna W L de GeusJennifer F Tseng
May 1, 2018·The British Journal of Surgery·E VersteijneUNKNOWN Dutch Pancreatic Cancer Group
Sep 13, 2012·Experimental and Therapeutic Medicine·Hidehiro TajimaSeiko Kitamura
Jul 16, 2010·Scandinavian Journal of Gastroenterology·Martin KlimentFrantisek Jaluvka
Jul 2, 2021·World Journal of Gastrointestinal Surgery·Gennaro NappoAlessandro Zerbi

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