Neoadjuvant Chemoradiotherapy for Patients with cT3/Nearly T4 Esophageal Cancer: Is Sarcopenia Correlated with Postoperative Complications and Prognosis?

World Journal of Surgery
Hiroshi SaekiYoshihiko Maehara

Abstract

Since the clinical impact of sarcopenia on multimodal therapy for patients with esophageal cancer is not well understood, this study was conducted to determine the influence of sarcopenia on the efficacy of neoadjuvant chemoradiotherapy (NACRT) for locally advanced esophageal cancer. The skeletal muscle index was quantified at the level of the third lumbar vertebra on computed tomography images, and sarcopenia was defined as a skeletal muscle index that was less than the average for each gender. We compared treatment outcomes in patients with cT3 and nearly T4 thoracic esophageal squamous cell carcinoma between the sarcopenia group (n = 85) and the non-sarcopenia group (n = 72). The 5-year survival rates were 33.4% in the non-sarcopenia group and 31.5% in the sarcopenia group; these differences were not significant. The prognosis of the patients with sarcopenia was worse than that of the patients without sarcopenia in the surgery-alone group, but there was no difference between patients with and without sarcopenia in the NACRT group. NACRT could be a useful option for patients with locally advanced esophageal squamous cell carcinoma, even for those with sarcopenia, without increasing the incidence of morbidity and mortality.

References

Mar 1, 1995·World Journal of Surgery·U FinkJ R Siewert
May 1, 1997·The Journal of Nutrition·I H Rosenberg
Mar 20, 2002·The Annals of Thoracic Surgery·Christopher E AvendanoCarolyn E Reed
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J ArendsUNKNOWN ESPEN (European Society for Parenteral and Enteral Nutrition)
Mar 3, 2007·The Lancet Oncology·Val GebskiUNKNOWN Australasian Gastro-Intestinal Trials Group
Jul 2, 2008·Journal of Gastroenterology·Masaru MoritaYoshihiko Maehara
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Oct 6, 2010·The British Journal of Surgery·P M SafranekT C B Dehn
Aug 31, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sherif AwadDileep N Lobo
Jan 17, 2012·The British Journal of Surgery·M G van VledderJ N M Ijzermans
Apr 24, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomoharu YoshizumiYoshihiko Maehara
Aug 15, 2013·Annals of Surgical Oncology·Hiroshi SaekiYoshihiko Maehara
Dec 17, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B H L TanJ A Catton
Jan 8, 2015·Annals of Surgical Oncology·Yuji MiyamotoHideo Baba
Jul 1, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K HaradaH Baba
Nov 8, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Se-Il GoGyeong-Won Lee
Feb 18, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norifumi HarimotoYoshihiko Maehara
Mar 5, 2016·Journal of Surgical Oncology·Tatsuto NishigoriYoshiharu Sakai
Oct 22, 2016·World Journal of Surgery·Brechtje A GrotenhuisJ Jan B van Lanschot

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Citations

Sep 17, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sho DohzonoHiroaki Nakamura
Aug 8, 2019·Current Opinion in Supportive and Palliative Care·Shilpa Mukunda Chowdhry, Varun Kumar Chowdhry
Feb 11, 2020·Annals of Surgical Oncology·Pei-Yu WangYin Li
Mar 4, 2020·Journal of Cachexia, Sarcopenia and Muscle·Linda B M WeerinkGeertruida H de Bock
Mar 21, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Dimitrios PapaconstantinouEmmanouil Pikoulis
Nov 30, 2018·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Han-Yu DengXiao-Yun Li

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