Neoadjuvant chemotherapy and primary debulking surgery utilization for advanced-stage ovarian cancer at a comprehensive cancer center

Gynecologic Oncology
Jennifer J MuellerOliver Zivanovic

Abstract

The aim of this study was to evaluate the use of neoadjuvant chemotherapy (NACT) and primary debulking surgery (PDS) before and after results from a randomized trial were published and showed non-inferiority between NACT and PDS in the management of advanced-stage ovarian carcinoma. We evaluated consecutive patients with advanced-stage ovarian cancer treated at our institution from 1/1/08-5/1/13, which encompassed 32 months before and 32 months after the randomized trial results were published. We included all newly diagnosed patients with high-grade histology and stage III/IV disease. Associations between the use of NACT and clinical variables over time were evaluated. Our study included 586 patients. Median age was 62 years (range, 30-90); 406 patients (69%) had stage III disease, and 570 (97%) had disease of serous histology. Twenty-six percent (154/586) were treated with NACT and 74% (432/586) with PDS. NACT use increased significantly from 22% (56/256) before 2010 (at which point the results of the randomized trial were published) to 30% (98/330) after 2010 (p=0.037). Although patients who underwent PDS were more likely to experience grade 3/4 surgical complications than those who underwent NACT, those selected for PDS had...Continue Reading

References

Oct 12, 2010·Gynecologic Oncology·Giovanni D AlettiWilliam A Cliby
Sep 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dennis S ChiBeth Y Karlan
Dec 30, 2011·The New England Journal of Medicine·Robert A BurgerUNKNOWN Gynecologic Oncology Group
Feb 11, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil S HorowitzG Larry Maxwell
Feb 25, 2015·Nature Reviews. Clinical Oncology·Alpa M NickAnil K Sood

❮ Previous
Next ❯

Citations

Apr 26, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taymaa MayPrafull Ghatage
Mar 6, 2018·Cancer Biomarkers : Section a of Disease Markers·Li-Xia ZhongLi-Zhu Lin
Jan 20, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F MoroA C Testa
Aug 11, 2018·Obstetrics and Gynecology·Olga T Filippova, Dennis S Chi
Sep 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Eduardo PaulinoPaul E Goss
Oct 3, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Paulina CybulskaDennis S Chi
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Alexandra LearyMatthew Nankivell
Apr 12, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Judith E den OudenAnne M van Altena
Dec 29, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marianne J RuttenMarrije R Buist
May 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taymaa MayPrafull Ghatage
Jun 12, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ying L LiuWilliam Tew
Nov 3, 2020·Critical Reviews in Oncology/hematology·Riccardo Ponzone
Sep 19, 2020·Gynecologic Oncology·Charlotte PalmqvistPernilla Dahm-Kähler
Feb 11, 2021·Cancers·Ami PatelNicole D Fleming
Sep 27, 2018·Gynecologic Oncology·Oliver ZivanovicRoisin E O'Cearbhaill
Jul 20, 2021·Journal of Ovarian Research·Jorge A Alegría-BañosDiddier Prada-Ortega
Jul 28, 2021·Gynecologic Oncology·Derman BasaranElizabeth L Jewell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
V LoizziL Selvaggi
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Vilius RudaitisRamunas Janavicius
European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jean-Guillaume FerronPhilippe Morice
© 2022 Meta ULC. All rights reserved