Neoadjuvant chemotherapy followed by radical surgery in patients affected by vaginal carcinoma

Gynecologic Oncology
Pierluigi Benedetti PaniciRoberto Angioli

Abstract

Radiotherapy represents the standard treatment for patients affected by FIGO stage II vaginal cancer. Several authors have suggested that neoadjuvant chemotherapy followed by radical surgery might be a valid treatment option in patients affected by cervical cancer. The objective of this study was to analyse the feasibility and results obtained by neoadjuvant chemotherapy followed by surgery in patients affected by invasive vaginal cancer with paravaginal tissue involvement not reaching the pelvic side wall. Eleven patients affected by FIGO stage II vaginal cancer were treated with paclitaxel 175 mg/m(2) and cisplatin 75 mg/m(2) every 21 days for three courses followed by radical surgery. All patients were subjected to the 3 planned chemotherapy courses. Three (27%) patients achieved a complete clinical response and seven (64 %) patients achieved a partial clinical response. All patients were subjected to radical hysterectomy and vaginectomy. At a median follow up of 75 months two (18%) patients suffered a disease recurrence and one of these died of disease. Neoadjuvant chemotherapy followed by radical surgery is a feasible therapeutic strategy with good short- and long-term results. In women affected by vaginal cancer, a larger...Continue Reading

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Citations

Dec 17, 2014·The Journal of Obstetrics and Gynaecology Research·Yasushi MabuchiKazuhiko Ino
Dec 6, 2014·Critical Reviews in Oncology/hematology·Angiolo GadducciClaudia Sergiampietri
Jun 22, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Vandana JainSudhir Rawal
Jul 1, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Vandana JainSudhir Rawal
Sep 13, 2017·Molecular and Clinical Oncology·Yuchao DiaoQin Yao
Dec 13, 2019·Frontiers in Oncology·Wenhui WangSen Zhong

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