PMID: 9531375Apr 8, 1998Paper

Neoadjuvant chemotherapy followed by radiotherapy should not be a standard approach for locally advanced cervical cancer

International Journal of Radiation Oncology, Biology, Physics
P W ShuengH S Liu

Abstract

To investigate the role of neoadjuvant chemotherapy followed by radiotherapy in locally advanced cervical cancer. This study cites all known literature on the subject in the English language. Articles were selected for analysis by MEDLINE and CANCERLINE computer searches. In Phase II trials, the response rates of some selective series were analyzed. However, This article will specially emphasize the result of all Phase III randomized trials. Several investigators did obtain promising results from Phase II trials of neoadjuvant chemotherapy, mostly cisplatin-based combinations, followed by radiotherapy. However, most Phase III trials failed to demonstrate any benefit in terms of loco-regional relapse and/or survival by up-front chemotherapy. The role of neoadjuvant chemotherapy remains to be defined, and the search for more active new agents must be continued. The neoadjuvant setting is still experimental and could not be recommended as a standard treatment at the present.

References

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Citations

Mar 30, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P A CouckeH Phuoc Do
Sep 29, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J Dunst
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·N HoriiM Imamura
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J F TierneyM K Parmar
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E. T. M. De JongeR. Holm
Sep 21, 2016·Best Practice & Research. Clinical Gastroenterology·Thomas B Brunner
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A EisbruchT S Lawrence
May 18, 2010·Current Opinion in Oncology·Zeina Al-Mansour, Claire Verschraegen
Jul 7, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J Dunst, R Sauer
Nov 27, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·H Lindner
Jun 8, 2001·Journal of Radiation Research·C K NairT Nomura

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