Neoadjuvant Chemotherapy Followed by Chemoradiation in Cervical Carcinoma: A Review

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Carla Rameri Alexandre Silva de AzevedoCarlos Gil Ferreira

Abstract

Cervical cancer is a public health problem. A large proportion of patients have locally advanced (LA) disease at presentation and for this group, neoadjuvant chemotherapy (NACT) has an undefined role in the era of chemoradiotherapy. In countries with restricted access to radiotherapy, NACT may precipitate patients' access to an effective treatment approach. We carried out a systematic review to evaluate available data about NACT followed by chemoradiation. Studies evaluated the use of NACT followed by chemoradiotherapy. Search strategy was performed in MEDLINE, LILACS, and Cochrane Library from 2003 to 2013. Conference proceedings of American Society of Clinical Oncology annual meeting, International Journal of Gynecological Cancer Society biennial meeting, and European Society of Gynecological Oncology biennial meeting were also reviewed. Key words used were "cervical uterine cancer," "cervical uterine neoplasm," "neoadjuvant therapy," "neoadjuvant treatment," and "locally advanced." Data collected included author information, year of publication, study design, number of participants, eligibility criteria, treatment, response rate (RR), disease-free survival, overall survival, and toxicities. Initial searches retrieved 7670 re...Continue Reading

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Citations

Feb 14, 2020·Current Oncology Reports·Shinya MatsuzakiKoji Matsuo
May 28, 2020·DNA and Cell Biology·Jinhui LiuWenjun Cheng
Jan 21, 2021·Expert Review of Anticancer Therapy·Christine GennigensGuy Jerusalem

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