Neoadjuvant chemotherapy for locally advanced carcinoma of the lower oesophagus and oesophago-gastric junction

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
M J ForshawR C Mason

Abstract

To evaluate a single unit's experience with neoadjuvant chemotherapy for treating locally advanced non-metastatic initially resectable and unresectable oesophago-gastric cancer. The medical records of all patients with either locally advanced carcinoma of the lower oesophagus or cardia treated with neoadjuvant chemotherapy between August 1999 and January 2003 were reviewed. Sixty-four patients with initially resectable tumours (T2-3 or N+) and 38 patients with initially unresectable tumours (T4 or M1a) received neoadjuvant chemotherapy (83% combination Epirubicin, Cisplatin and 5-Fluorouracil). Symptomatic grade III/IV toxicity was observed in 33% of patients. Chemotherapy was not completed in 20 patients because of death (5.9%) and inadequate tumour response/toxicity (13.7%). Forty-three patients (67.3%) with initially resectable tumours and 19 patients (50%) with initially unresectable tumours underwent surgery. Chemotherapy in this study was associated with appreciable toxicity. Patients with initially unresectable locally advanced disease can be downstaged with neoadjuvant chemotherapy.

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Citations

Aug 30, 2011·Surgery Today·Yasunori Akutsu, Hisahiro Matsubara
Dec 1, 2009·Journal of Gastrointestinal Cancer·Duminda Subasinghe, Dharmabandhu Nandadeva Samarasekera
Mar 19, 2013·Annals of Surgical Oncology·Jose M PimientoKenneth L Meredith
Jan 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun-Rong WuXue Qin
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Jun 12, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·David A SchomasRobert C Miller
Dec 24, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E L A ToxopeusB P L Wijnhoven
Mar 28, 2008·The Korean Journal of Internal Medicine·Jong Yul JungHei-Cheul Jeung

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