Neoadjuvant chemotherapy is not a contraindication for nipple sparing mastectomy

The Breast : Official Journal of the European Society of Mastology
Stefano SantoroLucio Fortunato

Abstract

Nipple-sparing mastectomy (NSM) has been recently implemented to improve cosmetic outcome after mastectomy, but it is rarely considered today after neoadjuvant chemotherapy (NCH). Among 275 NSMs performed from January 2007 to January 2015, 186 cases, with a minimum follow-up of 12 months, were carried out for invasive or intraductal carcinoma. Patients were considered for NSM if there were no clinical and radiological evidence of invasion or close proximity (<1 cm) to the nipple-areola complex (NAC). We compared patients operated with NSM after NCH (Group I N = 51) with those who underwent primary surgery (Group II, N = 135). At a median follow-up of 35 months, 166/186 patients were alive and disease-free (89.7%). Three local relapses (1.6%) were observed, all in the skin flap outside the NAC in Group I: (6%; p < 0.01). No NAC recurrences have been recorded, in either group. Nipple loss due to full thickness necrosis or resection for insufficient margins was recorded in 31 cases (17%); 12 in Group I (24%) and 19 in Group II (14%) (P = 0.1). This event decreased by half in the second part of the study (21/93 vs 10/93) (P = 0.03). NSM after NCH is not associated with a statistically significant difference in terms of post-operati...Continue Reading

References

Nov 1, 1987·Plastic and Reconstructive Surgery·D K WellischJ W Little
Jun 28, 2005·Journal of the American College of Surgeons·Alan J Stolier, Baiba J Grube
Aug 1, 2009·Plastic and Reconstructive Surgery·Andrea L PusicStefan J Cano
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena F BrachtelFrederick C Koerner
Jul 3, 2010·Plastic and Reconstructive Surgery·Khayam AzzawiCharles M Malata
Jan 26, 2011·Cancer·Yue-Yung HuCaprice C Greenberg
Apr 2, 2011·International Journal of Surgical Pathology· Weidong Li Li Fu
Oct 4, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M DonkerM-J T F D Vrancken Peeters
Oct 5, 2011·The Breast : Official Journal of the European Society of Mastology·Secondo FolliFabio Falcini
Jan 31, 2012·The Breast Journal·Vijayashree Murthy, Ronald S Chamberlain
Apr 25, 2012·Annals of Surgical Oncology·Anne Warren PeledLaura J Esserman
Jun 1, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marta D'AlonzoRiccardo Ponzone
Sep 12, 2012·Annals of Surgical Oncology·Shawn T SteenArmando E Giuliano
Jan 9, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Délio Marques Conde, Renato Zocchio Torresan
Aug 6, 2013·Journal of Surgical Oncology·Lucio FortunatoCarlo E Vitelli
Aug 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Aug 27, 2013·Annals of Surgical Oncology·Suzanne B CoopeyBarbara L Smith
Aug 27, 2013·Annals of Surgical Oncology·Eric C BurdgeV Suzanne Klimberg
Mar 4, 2014·American Journal of Surgery·Shailesh AgarwalJayant P Agarwal

❮ Previous
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Citations

Jul 14, 2016·Annals of Surgical Oncology·Tina J HiekenJill R Dietz
Jul 7, 2016·Annals of Surgical Oncology·Tracy Ann MooRache Simmons
Feb 22, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Youichi MachidaEisuke Fukuma
Sep 16, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yvonne Ying-Ru NgBenita Kiat Tee Tan
May 28, 2019·Annals of Surgical Oncology·Alex J BartholomewEleni A Tousimis
May 22, 2016·BMJ Open·Riaz A AghaJennifer E Rusby
Oct 4, 2017·Southern Medical Journal·Sonia T OrcuttChristine Laronga
Oct 3, 2018·Plastic and Reconstructive Surgery. Global Open·Ryan E ReboweMaurice Y Nahabedian
Oct 16, 2018·Breast Care·Octavi CordobaCarmen Reyero-Fernández
Dec 20, 2019·Annals of Plastic Surgery·Oscar J ManriqueNho V Tran
Aug 14, 2018·Breast Cancer Research and Treatment·Fernanda Barbosa C RochaAntonio Luiz Frasson
Feb 3, 2021·Clinical Breast Cancer·Yuji YamashitaNaoki Hayashi
Jul 9, 2020·Annals of Medicine and Surgery·M Riis
Apr 19, 2021·Annals of Surgical Oncology·Tracy-Ann MooVirgilio Sacchini
May 12, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Alessandro De LucaLucio Fortunato

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