Neoadjuvant chemotherapy with cisplatin, aclacinomycin A, and mitomycin C for cervical adenocarcinoma--a preliminary study

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
T SaitoR Kudo

Abstract

Between 1989 and 2002, 28 patients with locally advanced cervical adenocarcinoma (bulky IB-IIIB) were recruited for a pilot study aimed at evaluation of the effectiveness of neoadjuvant chemotherapy with cisplatin, aclacinomycin-A, and mitomycin-C (PAM), followed by radical surgery. This regimen was administrated intra-arterially or intravenously. In addition to patients treated with PAM, we retrospectively analyzed the prognoses of 26 patients in stage I and II, who had been treated between 1975 and 1981 with radical surgery with/without radiation therapy. Twenty-eight patients received PAM therapy as neoadjuvant chemotherapy, and 75.0% of the 16 intra-arterially infused patients showed a response, as did 66.7% of the 12 intravenously infused patients. There was a significant difference in the 5-year prognosis of stage II (PAM group, 72.9%; without-PAM group, 36.4%). The results suggest that, as the free space in the parametrium is widened by neoadjuvant chemotherapy with PAM, it is possible that the tumor could be completely resected by radical hysterectomy. Thus, neoadjuvant chemotherapy with PAM is expected to improve the survival rate of patients with advanced cervical adenocarcinoma by the preliminary study. However, the ...Continue Reading

References

Sep 1, 1977·Gynecologic Oncology·K E Kjörstad
Oct 1, 1992·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·E W IpL C Wong
Jan 1, 1991·Gynecologic Oncology·P R DottinoC J Cohen
Apr 15, 1986·Cancer·P E SaigoJ L Lewis
Jul 1, 1989·Cardiovascular and Interventional Radiology·Y YamashitaH Okamura
Oct 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J KavanaghW S Roberts
Jan 15, 1986·Cancer·P J MobergG Söderberg
May 15, 1986·Cancer·R J Weiss, W E Lucas
Oct 1, 1984·American Journal of Obstetrics and Gynecology·K E Kjorstad, B Bond
Sep 1, 1983·Cancer·I Milsom, L G Friberg
Jun 1, 1982·Gynecologic Oncology·H K Tamimi, D C Figge
Dec 15, 1981·Cancer·J S BerekJ G Moore
Aug 1, 1995·Gynecologic Oncology·W T Creasman

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