Neoadjuvant chemotherapy with six cycles of carboplatin and paclitaxel in advanced ovarian cancer patients unsuitable for primary surgery: Safety and effectiveness

Gynecologic Oncology
Vanessa da Costa MirandaMaria Del Pilar Estevez Diz

Abstract

Three cycles of neoadjuvant chemotherapy (NACT) followed by interval debulking (ID) surgery is an alternative for patients with advanced ovarian cancer unresectable disease. This study aimed to determine the efficacy and safety of six cycles of NACT followed by cytoreduction. Retrospective analysis of all patients with advanced epithelial ovarian cancer, tubal carcinoma, or primary peritoneal carcinoma treated with platinum based NACT between January 2008 and February 2012. Eighty-two patients underwent NACT; 78% and 18.2% had extensive stage IIIC or IV disease at diagnosis, respectively. Their median age was 60 years (41-82). On histology, serous adenocarcinoma was found in 90.2%. Patients did not receive chemotherapy after debulking surgery. 35.4% suffered grade 3/4 toxicity; the most commonly observed toxicities were hematologic and nausea. After NACT, 23.1% experienced clinical complete response, 57.4% partial response, and 12.1% disease progression. Complete resection of all macroscopic and microscopic disease (R0) was performed in 63.7%. Surgical complications were uncommon; however, four (6.2%) patients needed a second procedure due to operative complications and 18 (27.3%) needed blood transfusion after debulking. Over ...Continue Reading

References

Dec 9, 1983·JAMA : the Journal of the American Medical Association·R C YoungJ P Smith
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert E BristowF J Montz
Dec 14, 2004·The New England Journal of Medicine·Peter G RoseUNKNOWN Gynecologic Oncology Group
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Dec 20, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·R Sankaranarayanan, J Ferlay
Sep 8, 2010·The New England Journal of Medicine·Ignace VergoteUNKNOWN NCIC Clinical Trials Group
Sep 29, 2011·Gynecologic Oncology·Melissa M ThrallBarbara A Goff
May 1, 2013·The Lancet Oncology·Paul E GossGustavo Azenha

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Citations

Oct 16, 2014·Gynecologic Oncology·John O SchorgeRichard T Penson
Dec 18, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F C Muñoz-CasaresF J Briceño
Jun 28, 2014·Frontiers in Oncology·Deborah J MarshAlexander J Cole
Feb 12, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Min-Hyun BaekJoo-Hyun Nam
Nov 5, 2014·Therapeutic Advances in Medical Oncology·Seiya Sato, Hiroaki Itamochi
Jun 21, 2017·Journal of Robotic Surgery·Sarah A AckroydBrent DuBeshter
Jul 30, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yulan RenRongyu Zang
Jun 26, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giacomo CorradoEnrico Vizza
Sep 27, 2018·Oncology Letters·Zhanfei LiZhengxing He
Aug 20, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Archana KumariS Radhika
Jun 6, 2015·Current Oncology Reports·Rachel Pounds, Sean Kehoe
Aug 31, 2017·Scientific Reports·Abel MatondoSung Soo Kim
Jul 7, 2019·Healthcare·Christopher G SmithFrederick R Ueland

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