Neoadjuvant Chemotherapy with Taxane and Platinum Followed by Radical Hysterectomy for Stage IB2-IIB Cervical Cancer: Impact of Histology Type on Survival

Journal of Clinical Medicine
Koji MatsuoToru Sugiyama

Abstract

The current study examined the histology-specific impact of neoadjuvant chemotherapy (NACT) with a taxane/platinum regimen on survival in women with locally-advanced cervical cancer who underwent radical hysterectomy. This nation-wide retrospective cohort study examined women with clinical stage IB2-IIB cervical cancer who received NACT prior to radical hysterectomy from 2004⁻2008 (n = 684). NACT type (taxane/platinum versus others) was correlated with survival based on histology: 511 squamous versus 173 non-squamous. Taxane/platinum chemotherapy use was more common in non-squamous compared to squamous tumors (53.8% versus 20.7%, P < 0.001). In both histology types, the taxane/platinum regimen was more frequently utilized over time (both, P < 0.01). Among squamous tumors, women who received taxane/platinum chemotherapy had survival comparable to those who received other regimens: 5-year rates for disease-free survival, 69.0% versus 70.1%, P = 0.98; and cause-specific survival, 80.0% versus 81.0%, P = 0.93. Similarly, in non-squamous tumors, disease-free survival (5-year rates: 60.4% versus 59.0%, P = 0.86) and cause-specific survival (74.7% versus 76.3%, P = 0.70) were similar. In conclusion, use of taxane/platinum regimens for...Continue Reading

References

Nov 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G ScambiaG Puglia
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P CurtinR D Alvarez
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierluigi Benedetti-PaniciFabio Landoni
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H MooreThomas F Rocereto
Jun 13, 2006·The Journal of Obstetrics and Gynaecology Research·Hong-Bing CaiHou-Han Yin
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley J MonkDavid Cella
Nov 3, 2009·Gynecologic Oncology·Lilian T GienGillian Thomas
Aug 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taisuke MoriJo Kitawaki
Oct 23, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H S KimJ W Kim
Nov 16, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliPierluigi Benedetti-Panici
Feb 21, 2014·The New England Journal of Medicine·Krishnansu S TewariBradley J Monk
Mar 19, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN FIGO Committee on Gynecologic Oncology
Aug 1, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mikio MikamiUNKNOWN Disease Committee of Uterine Cervical and Vulvar Cancer, Japanese Gynecologic Oncology Group
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Mar 4, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ryo KitagawaHiroyuki Yoshikawa
Mar 25, 2015·International Journal of Clinical Oncology·Yasuhiko EbinaHiroyuki Yoshikawa
May 28, 2015·Annals of Surgical Oncology·Alexandre A B A da CostaMaria Isabel W Achatz
Nov 23, 2016·The Cochrane Database of Systematic Reviews·Frederico S FalcettaDaniela D Rosa
Jan 24, 2017·Nature·UNKNOWN Cancer Genome Atlas Research NetworkUNKNOWN Washington University in St Louis
May 20, 2017·International Journal of Cancer. Journal International Du Cancer·Koji MatsuoToru Sugiyama
May 26, 2017·Journal of Gynecologic Oncology·Koji MatsuoMikio Mikami
Jun 3, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rawand SalihiIgnace Vergote
Oct 5, 2017·International Journal of Cancer. Journal International Du Cancer·Koji MatsuoToru Sugiyama
Feb 13, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sudeep GuptaRajendra Badwe

❮ Previous
Next ❯

Citations

May 15, 2019·Obstetrics and Gynecology·Koji MatsuoMikio Mikami
Feb 14, 2020·Current Oncology Reports·Shinya MatsuzakiKoji Matsuo
May 29, 2019·Obstetrics and Gynecology·Koji MatsuoMikio Mikami
Dec 15, 2020·The Tohoku Journal of Experimental Medicine·Muneaki ShimadaNobuo Yaegashi

❮ Previous
Next ❯

Methods Mentioned

BETA
hysterectomy

Software Mentioned

Statistical Package for Social Science SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.