Abstract
A prospective clinical trial was undertaken to investigate the feasibility of concurrent chemoradiotherapy for esophageal carcinomas. Between June 1989 and May 1996, forty patients with operable squamous cell carcinoma of the thoracic esophagus (Stage 0 to III: UICC 1987), ages 45 to 78 years (mean: 64), were enrolled in a study of neoadjuvant concurrent chemoradiotherapy followed by definitive high-dose radiotherapy (CRT group) or surgery (CRT-S group). Neoadjuvant chemoradiotherapy consisted of 44 Gy in 40 fractions for 4 weeks (2.2 Gy/2 Fr/day) through 10-MVX rays, with 2 courses of cisplatin (80-100 mg/body, mean: 60 mg/m2, Day 1, bolus injection) and 5-fluorouracil (500-1000 mg/body/day, mean: 400 mg/m2, Days 1-4, continuous infusion). After completion of neoadjuvant chemoradiotherapy, an intermediate clinical response was assessed by barium swallow, esophagoscopy with/without biopsy, EUS in most cases, thoracic and upper abdominal CT scan, and cervical US. Definitive chemoradiotherapy was performed in patients when regression of more than 75% was evident (CRT Group), and esophageal resection was indicated in those who remained at less than 75% (CRT-S Group). In CRT Group, a cumulative dose of 60-70 Gy for Tis, T1 and 65-7...Continue Reading
References
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T ZenoneJ P Gerard
Jun 11, 1992·The New England Journal of Medicine·A HerskovicB Emami
Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L R CoiaG E Hanks
Jun 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Y HishikawaT Miura
Jan 1, 1991·Oncology·K IsonoK Nakayama
Aug 1, 1988·Annals of Surgery·K SugimachiH Kuwano
Jan 1, 1989·International Journal of Radiation Oncology, Biology, Physics·A ChanK Arthur
Aug 1, 1989·The Annals of Thoracic Surgery·V L LackeyW J Anderson
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Nov 15, 1994·International Journal of Radiation Oncology, Biology, Physics·T OkawaA Yamada
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·T ArimotoY Kaneko
Nov 1, 1995·Japanese Journal of Cancer Research : Gann·H Kato
Feb 1, 1997·International Journal of Radiation Oncology, Biology, Physics·L E GasparM Graham
Citations
Jun 26, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Carlo CastoroErmanno Ancona
Aug 21, 2003·Cancer Treatment Reviews·Gregory D LeonardMichael Maher
Apr 24, 2001·International Journal of Radiation Oncology, Biology, Physics·J H KimY I Min
Nov 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Jan T W LimIvo A Olivotto
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·M MurakamiH Takeda
Jan 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J I Geh
Apr 19, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M MurakamiH Takeda
Sep 27, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y OkamotoY Kobashi
Dec 7, 2007·Annals of Surgical Oncology·Simon K H WongEnders K W Ng
Aug 22, 2008·AJR. American Journal of Roentgenology·Yuichiro YamabeRyuzo Sekiguchi
Jul 28, 2012·Indian Journal of Palliative Care·Rakesh KapoorSuresh C Sharma
Dec 19, 2012·The Annals of Thoracic Surgery·Colin SchiemanMark S Allen
Jun 26, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J D UrschelF W Sellke
Apr 19, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S AikoT Maehara
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Ken KatoUNKNOWN Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group (JCOG)
Jul 7, 2016·Japanese Journal of Clinical Oncology·Yusuke Sasaki, Ken Kato
Apr 16, 2013·Japanese Journal of Clinical Oncology·Ken KatoKen-ichi Yoshimura
Mar 1, 2006·International Journal of Radiation Oncology, Biology, Physics·Kazunari YamadaSatoru Matsusue
Jul 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Heitetsu SaiMasahiro Hiraoka
Nov 23, 2006·Acta Oncologica·Kazunari YamadaSatoru Matsusue
Mar 22, 2001·The British Journal of Surgery·J I GehR Glynne-Jones
Jul 28, 2007·The British Journal of Surgery·J Gardner-ThorpeS J Dwerryhouse
Feb 24, 2001·American Journal of Clinical Oncology·A B JaniL M Chen
Jun 17, 2000·American Journal of Clinical Oncology·M StuschkeH Sack
Jul 11, 2006·World Journal of Gastroenterology : WJG·Frederic Di FiorePierre Michel
Aug 21, 2019·Cancer Medicine·Matteo FassanMarco Scarpa
May 21, 2005·Journal of Surgical Oncology·Hirmasa FujitaHiroki Inutsuka
May 29, 2021·The Surgical Clinics of North America·Romulo FajardoCharles T Bakhos
Aug 26, 2021·Clinical and Translational Radiation Oncology·Tatsuya SuwaTakashi Mizowaki